Scherlinger, M., & Tsokos, G. C. (2023). Neurotransmitters arrive to control systemic autoimmunity. Cell Metab, 35, 728-729.
Abstract
Immune cell microenvironment plays a major role in the aberrant function of immune cells in systemic lupus erythematosus. Zeng and co-authors show that in human and murine lupus, splenic stromal cell-derived acetylcholine switches B cell metabolism to fatty acid oxidation and promotes B cell autoreactivity and disease development.
Last updated on 02/17/2024