3D inhomogeneous magnetization transfer and rapid gradient echo (ihMTRAGE) imaging. International Society for Magnetic Resonance in Medicine 5503 (2018).
The inhomogeneous magnetization transfer (ihMT) technique provides a myelin-sensitive signal and has been applied for 3D acquisition in the steady-state. Sequences applied in a segmented fashion, following some magnetization preparation, provide an advantage of allowing insertion of additional modules, e.g. motion correction. An ihMT acquisition in the style of the magnetization-prepared rapid gradient-echo sequence was designed based on considerations of safety, hardware and optimizing the ihMT signal. Whole brain 3D ihMT data with 2.4mm isotropic resolution was achieved in 6-7mins. IhMT ratios between 15-20% were measured in white matter areas, and were not significantly modified by inclusion of a prospective motion correction module.