Dennis, E. L., Disner, S. G., Fani, N., Salminen, L. E., Logue, M., Clarke, E. K., Haswell, C. C., Averill, C. L., Baugh, L. A., Bomyea, J., Bruce, S. E., Cha, J., Choi, K., Davenport, N. D., Densmore, M., Plessis, S., Forster, G. L., Frijling, J. L., Gonenc, A., … Morey, R. A. (2021). Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium. Mol Psychiatry, 26, 4315-4330.
NOTES
1476-5578Dennis, Emily LOrcid: 0000-0001-7112-4009Disner, Seth GFani, NegarOrcid: 0000-0002-7720-252xSalminen, Lauren ELogue, MarkClarke, Emily KOrcid: 0000-0003-3553-2990Haswell, Courtney CAverill, Christopher LBaugh, Lee ABomyea, JessicaBruce, Steven ECha, JiookChoi, KyleDavenport, Nicholas DDensmore, Mariadu Plessis, StefanForster, Gina LFrijling, Jessie LGonenc, AtillaGruber, StaciGrupe, Daniel WOrcid: 0000-0003-4927-7572Guenette, Jeffrey POrcid: 0000-0002-4684-5469Hayes, JasmeetHofmann, DavidIpser, JonathanJovanovic, TanjaKelly, SineadKennis, MitzyKinzel, PhilippKoch, Saskia B JOrcid: 0000-0002-3628-6712Koerte, IngaOrcid: 0000-0003-1281-9286Koopowitz, SheriKorgaonkar, MayureshKrystal, JohnLebois, Lauren A MOrcid: 0000-0001-5816-9181Li, GenMagnotta, Vincent AManthey, AntjeMay, Geoff JMenefee, Deleene SNawijn, LauraNelson, Steven MNeufeld, Richard W JNitschke, Jack BO'Doherty, DanielPeverill, MatthewOrcid: 0000-0002-8257-1004Ressler, Kerry JRoos, AnnerineSheridan, Margaret ASierk, AnikaOrcid: 0000-0002-1396-8075Simmons, AlanSimons, Raluca MSimons, Jeffrey SStevens, JenniferOrcid: 0000-0003-4674-0314Suarez-Jimenez, BenjaminSullivan, Danielle ROrcid: 0000-0002-0141-5887Théberge, JeanOrcid: 0000-0001-7578-4469Tran, Jana Kvan den Heuvel, LeighOrcid: 0000-0003-3884-4754van der Werff, Steven J Avan Rooij, Sanne J HOrcid: 0000-0002-0160-7248van Zuiden, MirjamVelez, CarmenVerfaellie, MiekeVermeiren, Robert R J MWade, Benjamin S CWager, TorOrcid: 0000-0002-1936-5574Walter, HenrikOrcid: 0000-0002-9403-6121Winternitz, SherryWolff, JonathanYork, GeraldZhu, YeZhu, XiAbdallah, Chadi GOrcid: 0000-0001-5783-6181Bryant, RichardOrcid: 0000-0002-9607-819xDaniels, Judith KDavidson, Richard JFercho, Kelene AFranz, CarolGeuze, ElbertOrcid: 0000-0003-3479-2379Gordon, Evan MKaufman, Milissa LKremen, William SLagopoulos, JimLanius, Ruth ALyons, Michael JMcCauley, Stephen RMcGlinchey, ReginaMcLaughlin, Katie AMilberg, WilliamNeria, YuvalOlff, MirandaSeedat, SorayaOrcid: 0000-0002-5118-786xShenton, MarthaSponheim, Scott ROrcid: 0000-0002-2782-0856Stein, Dan JOrcid: 0000-0001-7218-7810Stein, Murray BOrcid: 0000-0001-9564-2871Straube, ThomasTate, David FOrcid: 0000-0003-0213-1920van der Wee, Nic J AVeltman, Dick JWang, LiWilde, Elisabeth AThompson, Paul MKochunov, PeterJahanshad, NedaMorey, Rajendra AR01 DA035484/DA/NIDA NIH HHS/United StatesF32 MH109274/MH/NIMH NIH HHS/United StatesR01 EB015611/EB/NIBIB NIH HHS/United StatesI01 CX000715/CX/CSRD VA/United StatesR01 MH116147/MH/NIMH NIH HHS/United StatesI01 CX001542/CX/CSRD VA/United StatesR01 MH119227/MH/NIMH NIH HHS/United StatesT32 MH018931/MH/NIMH NIH HHS/United StatesS10 OD023696/OD/NIH HHS/United StatesK01 MH118467/MH/NIMH NIH HHS/United StatesIK2 RX000709/RX/RRD VA/United StatesP41 EB015922/EB/NIBIB NIH HHS/United StatesR38 AI140299/AI/NIAID NIH HHS/United StatesP30 HD003352/HD/NICHD NIH HHS/United StatesR56 MH071537/MH/NIMH NIH HHS/United StatesR01 AG058822/AG/NIA NIH HHS/United StatesIK2 RX002922/RX/RRD VA/United StatesR21 MH098212/MH/NIMH NIH HHS/United StatesK12 HD085850/HD/NICHD NIH HHS/United StatesU54 AG062334/AG/NIA NIH HHS/United StatesR01 MH071537/MH/NIMH NIH HHS/United StatesR01 MH117292/MH/NIMH NIH HHS/United StatesIK2 CX001680/CX/CSRD VA/United StatesUL1 TR001863/TR/NCATS NIH HHS/United StatesR21 MH112956/MH/NIMH NIH HHS/United StatesK01 MH118428/MH/NIMH NIH HHS/United StatesR01 MH105355/MH/NIMH NIH HHS/United StatesM01 RR000039/RR/NCRR NIH HHS/United StatesR01 MH111671/MH/NIMH NIH HHS/United StatesK99 NS096116/NS/NINDS NIH HHS/United StatesIK1 RX002325/RX/RRD VA/United StatesI01 RX000622/RX/RRD VA/United StatesU54 EB020403/EB/NIBIB NIH HHS/United StatesR01 MH117601/MH/NIMH NIH HHS/United StatesUL1 TR000454/TR/NCATS NIH HHS/United StatesR56 AG058854/AG/NIA NIH HHS/United StatesK23 MH101380/MH/NIMH NIH HHS/United StatesR01 MH043454/MH/NIMH NIH HHS/United StatesK01 MH109836/MH/NIMH NIH HHS/United StatesIK2 CX001772/CX/CSRD VA/United StatesK23 MH101498/MH/NIMH NIH HHS/United StatesR01 HD071982/HD/NICHD NIH HHS/United StatesK23 MH090366/MH/NIMH NIH HHS/United StatesR01 AG022381/AG/NIA NIH HHS/United StatesR01 AG050595/AG/NIA NIH HHS/United StatesR01 AG059874/AG/NIA NIH HHS/United StatesJournal ArticleMeta-AnalysisResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Mol Psychiatry. 2021 Aug;26(8):4315-4330. doi: 10.1038/s41380-019-0631-x. Epub 2019 Dec 19.
Abstract
A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d = -0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.
Last updated on 03/06/2023