The goal of this study is to test the hypothesis that repeated exposure to cycles of insufficient sleep increases susceptibility to a variety of disease states by progressively compromising the integrity of stress response systems. We will test whether the hypothalamic-pituitary, sympatho-adrenal, and inflammatory stress response sensitize across repeated cycles of sleep restriction.
NIH/NHLBI R01 HL105544 [PI Monika Haack] 06/01/2011 – 04/31/2016