The primary goal of this project is to gather preliminary support for the hypothesis that deficient sleep leads to pain amplification through an inflammatory mechanism while the secondary goal is to investigate the potential mechanisms contributing to blood pressure reduction in response to aspirin taken at bedtime. Autonomic and renal regulation of blood pressure, as well as nitric oxide levels, will be monitored during sleep and sleep disruption after 2 weeks of pharmacological intervention (low-dose aspirin or placebo taken in the morning or at bedtime).
