About

A Harvard/BIDMC Laboratory

The Sloane Lab 

Multiple Sclerosis is the most common source of neurologic disability in young adults. Many treatments exist focussing on preventing MS relapses, but treatments for neurologic progression is still a significant unmet need. We research the sources of MS disability using a variety of tools, including MRI and clinical exam metrics. We also study the ability to recover, repair, and remyelinate in MS.

Woman scientist using microscope

Research Area

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Here is where you can talk about the variety of research subjects, topics, disciplines, sub-disciplines and themes that interest you. This section can include the work or research that you are already in the process of doing, or it can be aspirational: the type of research you would like to do in the future. The more content you include in this section, and the more specific your keywords, the more you will be associated with these keywords in an OpenScholar global search--which is great for finding research collaboration opportunities.

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Research Area

Multiple sclerosis progression 

With scientific advances, terminology changes. We used to think that (1) relapses are a primary source of MS disability, and that (2) MS subtypes are relatively distinct and separate. Now, we know that PIRA (progression independent of relapse activity) is the primary source of MS disability and that PIRA starts early even with relapsing-remitting MS. We have a very good handle of why relapses occur and how prevent them, but we have limited tools to prevent progression. What causes progression? What neuropathology is the source of progression? These are fundamental but mostly unanswered questions in MS research, even today! In the Sloane lab, we use clinical and radiological tools to get at these questions. 

 

Roche | MS measurements explained