Kang, Anthony D, Kenneth P Smith, Anders H Berg, Katherine A Truelson, George M Eliopoulos, Christopher McCoy, and James E Kirby. 2018. “Efficacy of Apramycin Against Multidrug-Resistant Acinetobacter Baumannii in the Murine Neutropenic Thigh Model.”. Antimicrobial Agents and Chemotherapy 62 (4).
Abstract
Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum (Cmax)/MIC was ≈10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii.