Hirsch, Elizabeth B, Paola C Zucchi, Alice Chen, Brian R Raux, James E Kirby, Christopher McCoy, and George M Eliopoulos. 2016. “Susceptibility of Multidrug-Resistant Gram-Negative Urine Isolates to Oral Antibiotics.”. Antimicrobial Agents and Chemotherapy 60 (5): 3138-40.
Abstract
Increasing resistance among Gram-negative uropathogens limits treatment options, and susceptibility data for multidrug-resistant isolates are limited. We assessed the activity of five oral agents against 91 multidrug-resistant Gram-negative urine isolates that were collected from emergency department/hospitalized patients. Fosfomycin and nitrofurantoin were most active (>75% susceptibility). Susceptibilities to sulfamethoxazole-trimethoprim, ciprofloxacin, and ampicillin were ≤40%; empirical use of these agents likely provides inadequate coverage in areas with a high prevalence of multidrug-resistant uropathogens.