Publications by Year: 2007

2007

Qian, Qinfang, Karen Eichelberger, and James E Kirby. (2007) 2007. “Rapid Identification of Staphylococcus Aureus in Blood Cultures by Use of the Direct Tube Coagulase Test.”. Journal of Clinical Microbiology 45 (7): 2267-9.
Publisher's Version
Publisher's Version

Direct tube coagulase testing for identification of Staphylococcus aureus from BACTEC culture broth showed a sensitivity, a specificity, and positive and negative predicative values of 34%, 100%, 100%, and 80.2% with 2 h of incubation and 65%, 98.7, 99.7%, and 88.6% with 4 h of incubation. Anaerobic blood culture contributed significantly to the detection of S. aureus.

Wang, Yihong, Saryn Doucette, Qinfang Qian, and James E Kirby. (2007) 2007. “Yield of Primary and Repeat Induced Sputum Testing for Pneumocystis Jiroveci in Human Immunodeficiency Virus-Positive and -Negative Patients.”. Archives of Pathology & Laboratory Medicine 131 (10): 1582-4.
Publisher's Version
Publisher's Version

CONTEXT: Induced sputum sampling has an approximate 70% sensitivity for detection of Pneumocystis jiroveci in human immunodeficiency virus (HIV) patients. Bronchoalveolar lavage sampling has greater than 90% sensitivity but is a far more invasive procedure. Therefore, bronchoalveolar lavage testing is often recommended as a follow-up after a negative induced sputum. In HIV-negative patients, the utility of induced sputum testing is still not well defined.

OBJECTIVE: To determine whether repeat induced sputum sampling increases diagnostic yield and might thereby reduce the need for follow-up bronchoalveolar lavage sampling. To determine the utility of induced sputum sampling in HIV-negative patients.

DESIGN: A 2-year retrospective review of the utility of repeat induced sputa testing in patients with previous first and/or second negative induced sputa. Retrospective review of induced sputa detection in HIV-negative patients.

RESULTS: Repeat testing of induced sputa for Pneumocystic jirovecii did not significantly increase diagnostic yield. Furthermore, in HIV-negative patients, induced sputum testing was diagnostically insensitive.

CONCLUSIONS: Bronchoalveolar lavage testing should be performed initially in HIV-negative patients and after a first negative induced sputum in HIV-positive patients.