BIDMC Glycomics Core Launches SUGA for Rapid N-Glycan Profiling

Many biologically critical proteins such as viral surface proteins (including SARS-CoV-2 spike), antibodies, and cell-surface receptors are heavily glycosylated, and these sugars can profoundly influence protein function, stability, immune recognition, and drug response. A new Journal of Proteome Research study from the BIDMC Glycomics Core introduces Swift Universal Glycan Acquisition (SUGA), a direct-injection electrospray ionization (ESI-MS) method that enables quantitative N-glycan compositional profiling in ~3 minutes per sample, without liquid chromatography or permethylation.

SUGA provides a fast, high-throughput way to understand what glycan features are present in proteins, cells, or biofluids, making it ideal for screening, comparative studies, and time-course experiments. In addition to SUGA, the Glycomics Core offers comprehensive glycosylation services including structural glycan analysis, site-specific N- and O-glycosylation mapping, glycolipid profiling, sialic acid linkage analysis, and glycan microarrays, helping investigators uncover biology that traditional proteomics or genomics alone cannot reveal.

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