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Indirect calorimetry data for one mouse implanted with a glucose and body temperature telemetry probe in the Promethion indirect calorimeter. Food was removed 1 h before start of the dark photoperiod (grey) and mice enter bouts of torpor (Rubio et al Mol Metabolism 2023)​

Germ-free mice can be examined using isolator cages (bottom). With this approach, we canexamine the metabolic profile of germ-free mice or mice colonized with specific microbes. ​

Thermal imaging was performed using FLIR on juvenile mice placed in a sterile 6-well culture dish to visualize body temperature distribution.

Body composition was measured using the Echo MRI 3-in-1 system and plotted in CalR, with fat, lean, and total mass shown on the left and corresponding percentage composition on the right. ​

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Energy Balance Metabolic Core at BIDMC and Harvard Medical School is a facility designed for the measurement of energy intake, nutritional status, and energy expenditure in experimental mice. CalR Equipment & Technologies Example Experiments

Thermogenesis: cold temperature challenge Thermogenesis: beta-adrenergic agonist activation of mice housed at thermoneutral temperatures Pharmacologic induction of metabolic rate (T3) Diet-induced obesity Optogenetic stimulation of food intake Chemogenetic stimulation of metabolism Induction of...

PARR Instruments Bomb Calorimeter Determines energy content of food or fecal matter FLIR Thermal Imaging Camera Determines thermal radiation

Highly Cited Research from the Core Many discoveries have relied upon careful measurement of body composition and metabolic rates in un-anesthetized, freely moving mice. One metric to determine the impact of a scientific publication is how many times other scientific articles have referred to that...

Beth Israel Deaconess Medical Center and Harvard Medical School - The home of CalR Energy Balance Metabolic Core at BIDMC and Harvard Medical School is a facility designed for the measurement of energy intake, nutritional status, and energy expenditure in experimental mice. This facility consists of...