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143 results found

Genetic predisposition to mosaic Y chromosome loss in blood

Publication: Journal Article

Thompson, Deborah, Giulio Genovese, Jonatan Halvardson, Jacob Ulirsch, Daniel Wright, Chikashi Terao, Olafur Davidsson, et al. 2019. “Genetic Predisposition to Mosaic Y Chromosome Loss in Blood”. Nature 575 (7784): 652-57.

Genes with High Network Connectivity Are Enriched for Disease Heritability

Publication: Journal Article

Kim, Samuel, Chengzhen Dai, Farhad Hormozdiari, Bryce Geijn, Steven Gazal, Yongjin Park, Luke O’Connor, et al. 2019. “Genes With High Network Connectivity Are Enriched for Disease Heritability”. Am J Hum Genet 104 (5): 896-913.

Leveraging Polygenic Functional Enrichment to Improve GWAS Power

Publication: Journal Article

Kichaev, Gleb, Gaurav Bhatia, Po-Ru Loh, Steven Gazal, Kathryn Burch, Malika Freund, Armin Schoech, Bogdan Pasaniuc, and Alkes Price. 2019. “Leveraging Polygenic Functional Enrichment to Improve GWAS Power”. Am J Hum Genet 104 (1): 65-75.

A model and test for coordinated polygenic epistasis in complex traits

Publication: Journal Article

Sheppard, Brooke, Nadav Rappoport, Po-Ru Loh, Stephan Sanders, Noah Zaitlen, and Andy Dahl. 2021. “A Model and Test for Coordinated Polygenic Epistasis in Complex Traits”. Proc Natl Acad Sci U S A 118 (15): e1922305118.

Liability threshold modeling of case-control status and family history of disease increases association power

Publication: Journal Article

Hujoel, Margaux, Steven Gazal, Po-Ru Loh, Nick Patterson, and Alkes Price. 2020. “Liability Threshold Modeling of Case-Control Status and Family History of Disease Increases Association Power”. Nat Genet 52 (5): 541-47.

Monogenic and polygenic inheritance become instruments for clonal selection

Publication: Journal Article

Loh, Po-Ru, Giulio Genovese, and Steven McCarroll. 2020. “Monogenic and Polygenic Inheritance Become Instruments for Clonal Selection”. Nature 584 (7819): 136-41.

Incorporating family history of disease improves polygenic risk scores in diverse populations

Publication: Journal Article

Hujoel, Margaux LA, Po-Ru Loh, Benjamin Neale, and Alkes Price. 2022. “Incorporating Family History of Disease Improves Polygenic Risk Scores in Diverse Populations”. Cell Genom 2 (7): 100152.

Chromosomal phase improves aneuploidy detection in non-invasive prenatal testing at low fetal DNA fractions

Publication: Journal Article

Genovese, Giulio, Curtis Mello, Po-Ru Loh, Robert Handsaker, Seva Kashin, Christopher Whelan, Lucy Bayer-Zwirello, and Steven McCarroll. 2022. “Chromosomal Phase Improves Aneuploidy Detection in Non-Invasive Prenatal Testing at Low Fetal DNA Fractions”. Sci Rep 12 (1): 12025.

Genome-wide mapping of somatic mutation rates uncovers drivers of cancer

Publication: Journal Article

Sherman, Maxwell A, Adam Yaari, Oliver Priebe, Felix Dietlein, Po-Ru Loh, and Bonnie Berger. 2022. “Genome-Wide Mapping of Somatic Mutation Rates Uncovers Drivers of Cancer”. Nat Biotechnol.

Maxwell A. Sherman

Person: Ph.D. Student, MIT Electrical Engineering and Computer Science (EECS), -> Co-Founder & CTO, Serinus Biosciences

Max is a PhD student in Electrical Engineering and Computer Science (EECS) at MIT. He previously studied applied mathematics at Brown University and theoretical statistics at the University of Cambridge before working as a scientific programmer in Peter Park's computational genomics group at Harvard...