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Thrombospondin Function

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TSP-1 is released from human blood platelets in response to thrombin treatment and was thus, designated thrombospondin in 1978. Since that time, four other members of the TSP gene family have been discovered. The TSPs are widely expressed in embryonic tissue. However, expression in adult tissue is...

Jack Lawler's thrombospondin research

The Lawler lab's in-depth knowledge of thrombospondin (TSP) structure and function has led to the development of a novel therapeutic for the treatment of ovarian and pancreatic cancer.

Identification of novel beta1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1.

Publication: Journal Article

Calzada, Maria J, Douglas S Annis, Bixi Zeng, Cezary Marcinkiewicz, Bernhard Banas, Jack Lawler, Deane F Mosher, and David D Roberts. 2004. “Identification of Novel Beta1 Integrin Binding Sites in the Type 1 and Type 2 Repeats of Thrombospondin-1.”. The Journal of Biological Chemistry 279 (40): 41734-43.

Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice.

Publication: Journal Article

Pimanda, John E, Tim Ganderton, Akiko Maekawa, Cindy L Yap, Jack Lawler, Geoff Kershaw, Colin N Chesterman, and Philip J Hogg. 2004. “Role of Thrombospondin-1 in Control of Von Willebrand Factor Multimer Size in Mice.”. The Journal of Biological Chemistry 279 (20): 21439-48.

Thrombospondin-1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliteration.

Publication: Journal Article

Wang, Shoujian, Zhifeng Wu, Christine M Sorenson, Jack Lawler, and Nader Sheibani. 2003. “Thrombospondin-1-Deficient Mice Exhibit Increased Vascular Density During Retinal Vascular Development and Are Less Sensitive to Hyperoxia-Mediated Vessel Obliteration.”. Developmental Dynamics : An Official Publication of the American Association of Anatomists 228 (4): 630-42.

Thrombospondin-1 plays a critical role in the induction of hair follicle involution and vascular regression during the catagen phase.

Publication: Journal Article

Yano, Kiichiro, Lawrence F Brown, Jack Lawler, Tokichi Miyakawa, and Michael Detmar. 2003. “Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase.”. The Journal of Investigative Dermatology 120 (1): 14-9.

Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication.

Publication: Journal Article

Tan, Kemin, Mark Duquette, Jin-huan Liu, Yicheng Dong, Rongguang Zhang, Andrzej Joachimiak, Jack Lawler, and Jia-huai Wang. 2002. “Crystal Structure of the TSP-1 Type 1 Repeats: A Novel Layered Fold and Its Biological Implication.”. The Journal of Cell Biology 159 (2): 373-82.

Cartilage oligomeric matrix protein (thrombospondin-5) is expressed by human vascular smooth muscle cells.

Publication: Journal Article

Riessen, R, M Fenchel, H Chen, D I Axel, K R Karsch, and J Lawler. 2001. “Cartilage Oligomeric Matrix Protein (thrombospondin-5) Is Expressed by Human Vascular Smooth Muscle Cells.”. Arteriosclerosis, Thrombosis, and Vascular Biology 21 (1): 47-54.

The cell biology of thrombospondin-1.

Publication: Journal Article

Chen, H, M E Herndon, and J Lawler. 2000. “The Cell Biology of Thrombospondin-1.”. Matrix Biology : Journal of the International Society for Matrix Biology 19 (7): 597-614.

The thrombospondin-4 gene.

Publication: Journal Article

Newton, G, S Weremowicz, C C Morton, N A Jenkins, D J Gilbert, N G Copeland, and J Lawler. 1999. “The Thrombospondin-4 Gene.”. Mammalian Genome : Official Journal of the International Mammalian Genome Society 10 (10): 1010-6.