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tRNA modifications are required for stress granule formation and melanoma metastasis.

Publication: Journal Article

Hughes, Riley O, Hannah J Davis, Leona A Nease, Paul Zumbo, Mauro Danielli, Wyatt Tran, Kilian Maidhof, et al. 2025. “TRNA Modifications Are Required for Stress Granule Formation and Melanoma Metastasis.”. BioRxiv : The Preprint Server for Biology.

Farewell to Jihoon

News: June 26, 2020

Jihoon is heading to the University of Florida to start his medical degree! We are sad to say goodbye but were glad to have him in the lab for two years.

Towards Personalized MicroRNA Therapeutics

News: July 23, 2020

Towards Personalized MicroRNA Therapeutics, presented by Dr. Frank Slack at the 2020 Virtual Nanomedicine Symposium hosted by Precision Nanosystems.

Undergraduate Researchers

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Francisca Lamini Francisca is a sophomore at Harvard College studying molecular and Cellular biology with a secondary in global health and health policy. She is also on the premed track. Ellie Shin Ellie is a junior at Harvard College studying Biomedical Engineering with a Language Citation in...

Alumni

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Slack Lab

Slack Lab, Frank Slack Lab, RNA research lab in BIDMC, The Slack Lab is at the forefront of the small RNA revolution, we co-discovered the second known miRNA and the ﬁrst human miRNA. Non-coding RNAs in Basic and Translational Research,

MicroRNA spatial profiling for assessing drug efficacy in BRCA1 -related triple-negative breast tumors.

Publication: Journal Article

Mohd, Omar N, Lin Wang, Brian R Sardella, David Jou, Gerburg M Wulf, Frank J Slack, Yujing J Heng, and Patrick S Doyle. 2026. “MicroRNA Spatial Profiling for Assessing Drug Efficacy in BRCA1 -Related Triple-Negative Breast Tumors.”. BioRxiv : The Preprint Server for Biology.

MicroRNAs in Aging

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We found that lin-4 mutants have short lifespans, while lin-4 over-expression extends lifespan and slows aging [1]. This was the ﬁrst report of a role for miRNAs in regulating lifespan, and led to an intense study in my lab of roles for miRNAs in aging. Initially, we performed high throughput...

Funding

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NIH/NIA- JUVENILE MICRORNAS PROMOTING HEALTHIER ADULT AGING: We showed first that microRNAs control aging and that they act upstream of insulin and insulin-like receptor (IIS) and other known longevity pathways. In this proposal, we propose to use discovery-based and hypothesis-based methods that we...

Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo.

Publication: Journal Article

Segal, Meirav, Annabelle Biscans, Maud-Emmanuelle Gilles, Eleni Anastasiadou, Roberto De Luca, Jihoon Lim, Anastasia Khvorova, and Frank J Slack. 2020. “Hydrophobically Modified Let-7b MiRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo.”. Molecular Therapy. Nucleic Acids 19: 267-77.