Search

Search results

227 results found

The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target.

Publication: Journal Article

Lin, Shin-Yi, Steven M Johnson, Mary Abraham, Monica C Vella, Amy Pasquinelli, Chiara Gamberi, Ellen Gottlieb, and Frank J Slack. 2003. “The C Elegans Hunchback Homolog, Hbl-1, Controls Temporal Patterning and Is a Probable MicroRNA Target.”. Developmental Cell 4 (5): 639-50.

Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression.

Publication: Journal Article

Lee, Soo Mi, Christopher L Avalos, Christos Miliotis, Hanna M Doh, Erica Chan, Kenneth M Kaye, and Frank J Slack. 2025. “Host MicroRNA-31-5p Represses Oncogenic Herpesvirus Lytic Reactivation by Restricting the RNA-Binding Protein KHDRBS3-Mediated Viral Gene Expression.”. BioRxiv : The Preprint Server for Biology.

tRNA modifications are required for stress granule formation and melanoma metastasis.

Publication: Journal Article

Hughes, Riley O, Hannah J Davis, Leona A Nease, Paul Zumbo, Mauro Danielli, Wyatt Tran, Kilian Maidhof, et al. 2025. “TRNA Modifications Are Required for Stress Granule Formation and Melanoma Metastasis.”. BioRxiv : The Preprint Server for Biology.

Farewell to Jihoon

News: June 26, 2020

Jihoon is heading to the University of Florida to start his medical degree! We are sad to say goodbye but were glad to have him in the lab for two years.

Towards Personalized MicroRNA Therapeutics

News: July 23, 2020

Towards Personalized MicroRNA Therapeutics, presented by Dr. Frank Slack at the 2020 Virtual Nanomedicine Symposium hosted by Precision Nanosystems.

Undergraduate Researchers

Page

Francisca Lamini Francisca is a sophomore at Harvard College studying molecular and Cellular biology with a secondary in global health and health policy. She is also on the premed track. Ellie Shin Ellie is a junior at Harvard College studying Biomedical Engineering with a Language Citation in...

Alumni

Page

Slack Lab

Slack Lab, Frank Slack Lab, RNA research lab in BIDMC, The Slack Lab is at the forefront of the small RNA revolution, we co-discovered the second known miRNA and the ﬁrst human miRNA. Non-coding RNAs in Basic and Translational Research,

MicroRNA spatial profiling for assessing drug efficacy in BRCA1 -related triple-negative breast tumors.

Publication: Journal Article

Mohd, Omar N, Lin Wang, Brian R Sardella, David Jou, Gerburg M Wulf, Frank J Slack, Yujing J Heng, and Patrick S Doyle. 2026. “MicroRNA Spatial Profiling for Assessing Drug Efficacy in BRCA1 -Related Triple-Negative Breast Tumors.”. BioRxiv : The Preprint Server for Biology.

MicroRNAs in Developmental Timing

Page

Our interest in miRNAs began with a desire to solve the fundamental question of how organs form at the right time during development [1, 4], and this core theme has since led us to a broader interest in the role of miRNAs in human disease and aging [5, 6]. We initially focused on using C. elegans to...