Search

Search results

56 results found

Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity.

Publication: Journal Article

Eikesdal, Hans Petter, Hikaru Sugimoto, Gabriel Birrane, Yohei Maeshima, Vesselina G Cooke, Mark Kieran, and Raghu Kalluri. 2008. “Identification of Amino Acids Essential for the Antiangiogenic Activity of Tumstatin and Its Use in Combination Antitumor Activity.”. Proceedings of the National Academy of Sciences of the United States of America 105 (39): 15040-5.

Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.

Publication: Journal Article

Varma, Ashok K, Raymond S Brown, Gabriel Birrane, and John A A Ladias. 2005. “Structural Basis for Cell Cycle Checkpoint Control by the BRCA1-CtIP Complex.”. Biochemistry 44 (33): 10941-6.

Gabriel Birrane, PhD

Person: Director of Structural Biology Core, Instructor in Medicine, Harvard Medical School

The Structural Biology Core Facility at Beth Israel Deaconess Medical Center, located at 99 Brookline Avenue (Research North), was established to provide state-of-the-art support for investigators across BIDMC, Harvard Medical School, and the broader biotechnology and pharmaceutical communities. Our...

Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity.

Publication: Journal Article

Chen, Yan Q, Ye Yang, Eugene Y Zhen, Thomas P Beyer, Hongxia Li, Yi Wen, Mariam Ehsani, et al. 2024. “Carboxyl-Terminal Sequences in APOA5 Are Important for Suppressing ANGPTL3/8 Activity.”. Proceedings of the National Academy of Sciences of the United States of America 121 (17): e2322332121.

Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.

Publication: Journal Article

Burak, Furkan, Karen E Inouye, Ariel White, Alexandra Lee, Gurol Tuncman, Ediz S Calay, Motohiro Sekiya, et al. 2015. “Development of a Therapeutic Monoclonal Antibody That Targets Secreted Fatty Acid-Binding Protein AP2 to Treat Type 2 Diabetes.”. Science Translational Medicine 7 (319): 319ra205.

Crystallization and preliminary X-ray analysis of a complex of the FOXO1 and Ets1 DNA-binding domains and DNA.

Publication: Journal Article

Choy, Wing W, Drishadwatti Datta, Catherine A Geiger, Gabriel Birrane, and Marianne A Grant. 2014. “Crystallization and Preliminary X-Ray Analysis of a Complex of the FOXO1 and Ets1 DNA-Binding Domains and DNA.”. Acta Crystallographica. Section F, Structural Biology Communications 70 (Pt 1): 44-8.

Crystal structure of the BARD1 BRCT domains.

Publication: Journal Article

Birrane, Gabriel, Ashok K Varma, Aditi Soni, and John A A Ladias. 2007. “Crystal Structure of the BARD1 BRCT Domains.”. Biochemistry 46 (26): 7706-12.

Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9.

Publication: Journal Article

Baek, Kyuwon, Raymond S Brown, Gabriel Birrane, and John A A Ladias. 2007. “Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-Dependent Kinase 9.”. Journal of Molecular Biology 366 (2): 563-73.

Jerome Groopman, MD

Person: Scientific Advisor of Structural Biology Core, Dina and Raphael Recanati Professor of Medicine, Harvard Medical School