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The goal of the Hide laboratory is to impact human health through understanding and translation of the underlying mechanisms of diseases. With the aim of providing effective therapies, our group works on discovery of genes, pathways and processes that drive disease development. We work assuming...

Tumor editing suppresses innate and adaptive antitumor immunity and is reversed by inhibiting DNA methylation.

Publication: Journal Article

Zhang, Ying, Pourya Naderi Yeganeh, Haiwei Zhang, Simon Yuan Wang, Zhouyihan Li, Bowen Gu, Dian-Jang Lee, et al. 2024. “Tumor Editing Suppresses Innate and Adaptive Antitumor Immunity and Is Reversed by Inhibiting DNA Methylation.”. Nature Immunology 25 (10): 1858-70.

Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.

Publication: Journal Article

Prokopenko, Dmitry, Sanghun Lee, Julian Hecker, Kristina Mullin, Sarah Morgan, Yuriko Katsumata, Alzheimer’s Disease Neuroimaging Initiative, et al. 2022. “Region-Based Analysis of Rare Genomic Variants in Whole-Genome Sequencing Datasets Reveal Two Novel Alzheimer’s Disease-Associated Genes: DTNB and DLG2.”. Molecular Psychiatry 27 (4): 1963-69.

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2.

Publication: Journal Article

Delorey, Toni M, Carly G K Ziegler, Graham Heimberg, Rachelly Normand, Yiming Yang, Åsa Segerstolpe, Domenic Abbondanza, et al. 2021. “A Single-Cell and Spatial Atlas of Autopsy Tissues Reveals Pathology and Cellular Targets of SARS-CoV-2.”. BioRxiv : The Preprint Server for Biology.

Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development.

Publication: Journal Article

Prokopenko, Dmitry, Sarah L Morgan, Kristina Mullin, Oliver Hofmann, Brad Chapman, Rory Kirchner, Sandeep Amberkar, et al. 2020. “Whole-Genome Sequencing Reveals New Alzheimer’s Disease-Associated Rare Variants in Loci Related to Synaptic Function and Neuronal Development.”. MedRxiv : The Preprint Server for Health Sciences.

Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.

Publication: Journal Article

Carling, Phillippa J, Heather Mortiboys, Claire Green, Simeon Mihaylov, Cynthia Sandor, Aurelie Schwartzentruber, Rosie Taylor, et al. 2020. “Deep Phenotyping of Peripheral Tissue Facilitates Mechanistic Disease Stratification in Sporadic Parkinson’s Disease.”. Progress in Neurobiology 187: 101772.

Evaluation of Risk of Injury by Extravasation of Hyperosmolar and Vasopressor Agents in a Rat Model.

Publication: Journal Article

Shibata, Yuuka, Yumeka Sagara, Tomoharu Yokooji, Takanori Taogoshi, Maiko Tanaka, Michihiro Hide, and Hiroaki Matsuo. 2018. “Evaluation of Risk of Injury by Extravasation of Hyperosmolar and Vasopressor Agents in a Rat Model.”. Biological & Pharmaceutical Bulletin 41 (6): 951-56.

Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment.

Publication: Journal Article

Li, Airong, Basavaraj Hooli, Kristina Mullin, Rebecca E Tate, Adele Bubnys, Rory Kirchner, Brad Chapman, Oliver Hofmann, Winston Hide, and Rudolph E Tanzi. 2017. “Silencing of the Drosophila Ortholog of SOX5 Leads to Abnormal Neuronal Development and Behavioral Impairment.”. Human Molecular Genetics 26 (8): 1472-82.

H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa.

Publication: Journal Article

Mulder, Nicola J, Ezekiel Adebiyi, Raouf Alami, Alia Benkahla, James Brandful, Seydou Doumbia, Dean Everett, et al. 2016. “H3ABioNet, a Sustainable Pan-African Bioinformatics Network for Human Heredity and Health in Africa.”. Genome Research 26 (2): 271-7.

Divergent LIN28-mRNA associations result in translational suppression upon the initiation of differentiation.

Publication: Journal Article

Tan, Shen Mynn, Gabriel Altschuler, Tian Yun Zhao, Haw Siang Ang, Henry Yang, Bing Lim, Leah Vardy, Winston Hide, Andrew M Thomson, and Ricky R Lareu. 2014. “Divergent LIN28-MRNA Associations Result in Translational Suppression Upon the Initiation of Differentiation.”. Nucleic Acids Research 42 (12): 7997-8007.