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I am a Postdoctoral Research Fellow at BIDMC and Harvard Medical School. My research centers on neuroinflammation and immune signaling in Alzheimer’s disease and related neurodegenerative and metabolic disorders, with a focus on glial and neuronal responses to pathological proteins such as amyloid-β...

Gut-Liver Axis and Acute-on-Chronic Liver Failure (ACLF)

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Gut-Liver Axis Excessive alcohol consumption results in GI tract dysfunction including disruption of the intestinal barrier and exposure of the liver to microbes and gut-derived pathogen-associated molecular patterns (PAMPs). The upper GI tract is exposed to the highest amount of alcohol but little...

Steatohepatitis - MASH/MetALD and Inflammation

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Danger signals and pathways of macrophage activation in MASH Inflammatory cell activation drives diverse cellular programming in steatohepatitis. Our studies revealed that activation of the multiprotein complex, inflammasome, contributes to metabolic dysfunction associated steatohepatitis (MASH)...

Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice.

Publication: Journal Article

Ambade, Aditya, Patrick Lowe, Karen Kodys, Donna Catalano, Benedek Gyongyosi, Yeonhee Cho, Arvin Iracheta-Vellve, et al. 2019. “Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice.”. Hepatology (Baltimore, Md.) 69 (3): 1105-21.

Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients.

Publication: Journal Article

Fasullo, Matthew, Prashanth Rau, Dong-Qi Liu, Erik Holzwanger, Jomol P Mathew, Yurima Guilarte-Walker, and Gyongyi Szabo. 2019. “Proton Pump Inhibitors Increase the Severity of Hepatic Encephalopathy in Cirrhotic Patients.”. World Journal of Hepatology 11 (6): 522-30.

Inhibition of the Inflammasome Signaling Cascade Reduces Alcohol Consumption in Female But Not Male Mice.

Publication: Journal Article

Lowe, Patrick P, Yeonhee Cho, David Tornai, Sahin Coban, Donna Catalano, and Gyongyi Szabo. 2020. “Inhibition of the Inflammasome Signaling Cascade Reduces Alcohol Consumption in Female But Not Male Mice.”. Alcoholism, Clinical and Experimental Research 44 (2): 567-78.

Deficiency of miR-208a Exacerbates CCl4-Induced Acute Liver Injury in Mice by Activating Cell Death Pathways.

Publication: Journal Article

Bala, Shashi, Charles D Calenda, Donna Catalano, Mrigya Babuta, Karen Kodys, Imad A Nasser, Barbara Vidal, and Gyongyi Szabo. 2020. “Deficiency of MiR-208a Exacerbates CCl4-Induced Acute Liver Injury in Mice by Activating Cell Death Pathways.”. Hepatology Communications 4 (10): 1487-1501.

Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations.

Publication: Journal Article

Lowe, Patrick P, Caroline Morel, Aditya Ambade, Arvin Iracheta-Vellve, Erica Kwiatkowski, Abhishek Satishchandran, Istvan Furi, et al. 2020. “Chronic Alcohol-Induced Neuroinflammation Involves CCR2/5-Dependent Peripheral Macrophage Infiltration and Microglia Alterations.”. Journal of Neuroinflammation 17 (1): 296.

Immune Response to an Acute Moderate Dose of Alcohol in Healthy Young Adults.

Publication: Journal Article

Monnig, Mollie A, Philip S Lamb, Jose M Parra, Patricia A Cioe, Christina M Martone, Peter M Monti, and Gyongyi Szabo. 2020. “Immune Response to an Acute Moderate Dose of Alcohol in Healthy Young Adults.”. Alcohol and Alcoholism (Oxford, Oxfordshire) 55 (6): 616-23.

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Neda Rezagholizadeh, PhD

Gut-Liver Axis and Acute-on-Chronic Liver Failure (ACLF)

Steatohepatitis - MASH/MetALD and Inflammation

Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice.

Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients.

Inhibition of the Inflammasome Signaling Cascade Reduces Alcohol Consumption in Female But Not Male Mice.

Deficiency of miR-208a Exacerbates CCl4-Induced Acute Liver Injury in Mice by Activating Cell Death Pathways.

Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations.

Immune Response to an Acute Moderate Dose of Alcohol in Healthy Young Adults.