Research Focus
The overarching goals of the lab are to accelerate the identification of novel therapeutic targets for human diseases by leveraging chemical biology tools and multi-omic human datasets.
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Preventable Deaths from Lack of High-Quality Medical Care Cost the World More Than $6 Trillion in 2015 Alone
Boston, Mass. — Deaths from treatable conditions may cost the world trillions of dollars each year, according to a newly published analysis led by Harvard Medical School researchers believed to be the first to quantify the economic impact of insufficient access to high-quality medical care. The...
Harvard Otolaryngology Spring 2018 issue
New Findings in Dystonia - Dr. Simonyan's research is highlighted in the Spring 2018 issue of Harvard Otolaryngology. “Continuation of [dystonia] research is vital in determining the exact causes and mechanisms of this disorder. This knowledge will be crucial for the future development of novel...
Congratulations to the Class of 2018
Thirty-two Harvard Ophthalmology/Mass. Eye and Ear clinical trainees graduated on June 21. The ceremony, held at Mass. Eye and Ear, celebrated eight Harvard Ophthalmology residents, the AY 2017-2018 chief resident, and two optometry residents, as well as 21 clinical fellows from Mass. Eye and Ear...
Research
Our lab integrates multiple complementary approaches, including: genetic discovery in human cohorts, genome editing in zebrafish and human cell models, mass spectrometry–based metabolite profiling, and high-throughput screening of small-molecule libraries. We apply these strategies across several...
Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity
H*, Sun, Takesian AE*, Wang TT, Lippman-Bell JJ, Hensch TK, and Jensen FE. 2018. “Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity”. Cell Reports 23 (9): 2533-40.
Corneal fluorescein staining and ocular symptoms but not Schirmer test are useful as indicators of response to treatment in chronic ocular GVHD
Amparo, Francisco, Hasanain Shikari, Ujwala Saboo, and Reza Dana. 2018. “Corneal Fluorescein Staining and Ocular Symptoms But Not Schirmer Test Are Useful As Indicators of Response to Treatment in Chronic Ocular GVHD”. Ocul Surf 16 (3): 377-81.
People with Hemianopia Report Difficulty with TV, Computer, Cinema Use, and Photography
Costela, Francisco, Sarah Sheldon, Bethany Walker, and Russell Woods. 2018. “People With Hemianopia Report Difficulty With TV, Computer, Cinema Use, and Photography”. Optom Vis Sci 95 (5): 428-34.
Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography
Diaz, Daniel, Jay Wang, Patrick Oellers, Inês Laíns, Lucia Sobrin, Deeba Husain, Joan Miller, Demetrios Vavvas, and John Miller. 2018. “Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography”. J Vitreoretin Dis 2 (3): 146-54.
Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus
Fan, Bao Jian, Xueli Chen, Nisha Sondhi, Ferdinamarie Sharmila, Nagasamy Soumittra, Sarangapani Sripriya, Srinivasan Sacikala, et al. 2018. “Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B As a Central Corneal Thickness Locus”. Invest Ophthalmol Vis Sci 59 (6): 2495-2502.