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Vida Karimnia, PhD

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Meet Vida Karimnia, our Omics Cores Navigator. With a Ph.D. in Biophysics, where she evaluated photodynamic therapy for targeting tumor-stroma and enhancing nanoparticle drug delivery in 3D tumor models, Vida possesses a deep understanding of cutting-edge technologies. Prior to her doctoral studies...

Slack Lab

Slack Lab, Frank Slack Lab, RNA research lab in BIDMC, The Slack Lab is at the forefront of the small RNA revolution, we co-discovered the second known miRNA and the first human miRNA. Non-coding RNAs in Basic and Translational Research,

 Cellular Atlas of Parkinson's Disease

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Detailed molecular characterization of cell-specific transcriptomic states throughout multiple brain regions beyond nigrostriatal dopaminergic degeneration will provide mechanistic insights into both motor and non-motor PD symptoms. We will integrate neuropathology and snRNA-Seq data to identify a...

Molecular Pathogenesis of Adult Onset Neuronal Lipofuscinosis

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In 2011, we discovered that mutations in the DNAJC5 gene cause a neurodegenerative disease, the autosomal dominant form of neuronal ceroid lipofuscinosis (AD-ANCL). DNAJC5 encodes cysteine-string protein alpha (CSPα). In subsequent studies, we demonstrated in vitro and in vivo that CSPα plays a...