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Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease
Lin, Michael T, Ippolita Cantuti-Castelvetri, Kangni Zheng, Katie E Jackson, Yong B Tan, Thomas Arzberger, Andrew J Lees, Rebecca Betensky, Flint Beal, and David K Simon. 2012. “Somatic Mitochondrial DNA Mutations in Early Parkinson and Incidental Lewy Body Disease”. Ann Neurol.
Peripheral Biomarkers of Parkinson's Disease Progression and Pioglitazone Effects.
Simon, DK, T Simuni, J Clark-Matott, AK Graebner, L Baker, SR Dunlop, M Emborg, et al. 2015. “Peripheral Biomarkers of Parkinson’s Disease Progression and Pioglitazone Effects.”. Journal of Parkinson’s Disease.
LRRK2 and Rab proteins
Leucine-rich repeat kinase 2 (LRRK2) is a critical protein associated with the pathogenesis of Parkinson's disease (PD), particularly through its influence on the endolysosomal system and the clearance of alpha-synuclein (aSyn) aggregates. The G2019S mutation in LRRK2 is the most prevalent...
Mitochondrial DNA mutations in Parkinson's disease brain
Simon, David K, Joanne Clark Matott, Janaina Espinosa, and Neeta A Abraham. 2017. “Mitochondrial DNA Mutations in Parkinson’s Disease Brain”. Acta Neuropathol Commun.
Our Team
Alejandra and Emily dive into research discussions during an engaging poster session
PGC-1α
Simon Lab: Lunchtime Science Chatter After a Successful Poster Presentation
Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease
Clark, Joanne, Sonika Reddy, Kangni Zheng, Rebecca A Betensky, and David K Simon. 2011. “Association of PGC-1alpha Polymorphisms With Age of Onset and Risk of Parkinson’s Disease”. BMC Med Genet.