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Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis.

Publication: Journal Article

Babuta, Mrigya, Caroline Morel, Marcelle de Carvalho Ribeiro, Charles Calenda, Martí Ortega-Ribera, Prashanth Thevkar Nagesh, Christopher Copeland, et al. 2024. “Neutrophil Extracellular Traps Activate Hepatic Stellate Cells and Monocytes via NLRP3 Sensing in Alcohol-Induced Acceleration of MASH Fibrosis.”. Gut.

Inflammasomes in chronic liver disease: Hepatic injury, fibrosis progression and systemic inflammation.

Publication: Journal Article

Taru, Vlad, Gyongyi Szabo, Wajahat Mehal, and Thomas Reiberger. 2024. “Inflammasomes in Chronic Liver Disease: Hepatic Injury, Fibrosis Progression and Systemic Inflammation.”. Journal of Hepatology.

IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.

Publication: Journal Article

Joshi, Radhika, Veronika Brezani, Gabrielle M Mey, Sergi Guixé-Muntet, Martí Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, and Gyongyi Szabo. 2024. “IRF3 Regulates Neuroinflammatory Responses and the Expression of Genes Associated With Alzheimer’s Disease.”. Journal of Neuroinflammation 21 (1): 212.

miR-21: A therapeutic target for delaying severe liver disease and hepatocellular carcinoma in high-fat-diet-fed mice.

Publication: Journal Article

Jagtap, Urmila, Anan Quan, Yuho Ono, Jonathan Lee, Kylie A Shen, Sergei Manakov, Gyongyi Szabo, Imad Nasser, and Frank J Slack. 2024. “MiR-21: A Therapeutic Target for Delaying Severe Liver Disease and Hepatocellular Carcinoma in High-Fat-Diet-Fed Mice.”. BioRxiv : The Preprint Server for Biology.

Funding

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Alchohol and Monocyte Signaling

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Macrophages (MØ), Kupffer cells (KC), and neutrophils mediate inflammation and play an important role in the pathogenesis of alcoholic liver disease (ALD). Previous studies have demonstrated the damaging effects of pro-inflammatory macrophages on alcoholic liver inflammation and high neutrophil...

microRNAs

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microRNA’s in Alcoholic Liver Disease Alcoholic liver disease affects millions of people worldwide and it remains to be a therapeutic challenge for clinicians. Activation of the inflammatory cascade via gut-derived lipopolysaccharide (LPS) contributes to alcoholic liver disease via induction of pro...

Clinical Alcoholic Hepatitis

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Alcoholic Hepatitis Clinical and Translational Network Late Phase Clinical Trials and Observational Studies Alcoholic liver disease (ALD) is a major cause of liver-related morbidity and mortality in the US. Alcoholic hepatitis (AH) is a life-threatening form of ALD. Severe AH is associated with a...

Radhika Joshi, PhD

Person: Postdoctoral Research Fellow

Radhika Joshi, PhD Radhika is studying the mechanism of alcohol induced neuroinflammation and its effects on features of Alzheimer disease.

Hannah Seigenberg, MS, BS

Person: Alumi-Senior Clinical Research Coordinator

Education: Bachelors in Neuroscience and Psychology and Masters in Neuroscience at Tulane University. Research Projects: As the Szabo Lab’s clinical research coordinator, I work on many of the clinical and translational research projects. My main project has been the Alcoholic Hepatitis Network...