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Funding

The National Institutes of Health (NINDS, NIA) provides funding for projects in our lab. We are also sincerely grateful to the patients, family members, and caregivers who donated their time, brains, and biospecimens for biomedical research.

Clinical Development of Fc3TSR

TSP-1 is a critical anti-angiogenic protein that counterbalances the pro-angiogenic activity of various factors, including VEGF, in normal physiology. Solid tumors are characterized by a tortuous vasculature, reduced perfusion, hypoxia, and high interstitial fluid pressure which impairs entry of...