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15] Facts About: UDP-Glucuronic Acid and Glucuronosyltransferases in the ER

Blog: January 13, 2025

By: Richard D. Cummings The endoplasmic reticulum (ER) of many types of cells contain members of a family of UDP-glucuronosyltransferases (UGTs). These enzymes utilize uridine diphosphate glucuronic acid (UDP-GlcA) as a donor and add GlcA to a tremendous variety of aglycone hydrophobic compounds...

16] Facts About: Major Glycoprotein in Urine – Uromodulin/Tamm-Horsfall Protein (THP)

Blog: February 03, 2025

By: Richard D. Cummings The major urinary glycoprotein is the Tamm-Horsfall protein (THP), also named uromodulin (Umod), and encoded by UMOD (1-4). Its concentration in urine can be as high as 1-2 mg/mL. It was discovered in 1950 by Tamm and Horsfall in their studies on compounds in urine that could...

ABO blood groups and galectins: Implications in transfusion medicine and innate immunity.

Publication: Journal Article

Arthur, Connie M, Marie Hollenhorst, Shang-Chuen Wu, Ryan Jajosky, Hirotomo Nakahara, Hau-Ming Jan, Leon Zheng, et al. 2024. “ABO Blood Groups and Galectins: Implications in Transfusion Medicine and Innate Immunity.”. Seminars in Immunology 74-75: 101892.

Unique Glycans in Synaptic Glycoproteins in Mouse Brain.

Publication: Journal Article

Noel, Maxence, Suttipong Suttapitugsakul, Mohui Wei, Catherine Tilton, Akul Y Mehta, Yasuyuki Matsumoto, Jamie Heimburg-Molinaro, Robert G Mealer, and Richard D Cummings. 2024. “Unique Glycans in Synaptic Glycoproteins in Mouse Brain.”. ACS Chemical Neuroscience 15 (21): 4033-45.

O-GalNAc glycans are enriched in neuronal tracts and regulate nodes of Ranvier.

Publication: Journal Article

Noel, Maxence, Suttipong Suttapitugsakul, Richard D Cummings, and Robert G Mealer. 2025. “O-GalNAc Glycans Are Enriched in Neuronal Tracts and Regulate Nodes of Ranvier.”. Proceedings of the National Academy of Sciences of the United States of America 122 (9): e2418949122.

Instructor in Glycoscience - BIDMC Harvard Medical School

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Date - September 3, 2025. The Department of Surgery at Beth Israel Deaconess Medical Center is immediately seeking applicants for a full-time faculty position at the level of Instructor in the area of Glycoscience. Areas of specific interest include glycomics and glycoproteomics, with experience in...

Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB

Publication: Journal Article

Nielsen, Morten Aagaard, Kristian Juul-Madsen, John Stegmayr, Chao Gao, Akul Y. Mehta, Stinne Ravn Greisen, Tue Wenzel Kragstrup, et al. 2022. “Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB”. Frontiers in Immunology Volume 13 - 2022.

Tianwei Jia

Person: Postdoctoral Research Fellow

Dr. Jia earned his Master's in Medicinal Chemistry in 2018 from Tianjin University of Science and Technology, working under the guidance of Prof. Yu Peng. His master’s research concentrated on the synthesis and characterization of glycol-nanoparticles, serving as probes to explore carbohydrate...

Kelsey M Charon

Person: Research Assistant

Kelsey received her bachelor's in Biological Engineering with a minor in Chemistry from Wentworth Institute of Technology (August 2023). As a Massachusetts native, she has been living and studying in Boston for the last several years. She has worked on projects with synthetic biology and cell...

Aeromonas hydrophila RTX adhesin has three ligand-binding domains that give the bacterium the potential to adhere to and aggregate a wide variety of cell types.

Publication: Journal Article

Ye, Qilu, Robert Eves, Tyler D R Vance, Thomas Hansen, Adam P Sage, Andrea Petkovic, Brianna Bradley, et al. 2025. “Aeromonas Hydrophila RTX Adhesin Has Three Ligand-Binding Domains That Give the Bacterium the Potential to Adhere to and Aggregate a Wide Variety of Cell Types.”. MBio 16 (5): e0315824.