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Many biologically critical proteins such as viral surface proteins (including SARS-CoV-2 spike), antibodies, and cell-surface receptors are heavily glycosylated, and these sugars can profoundly influence protein function, stability, immune recognition, and drug response. A new Journal of Proteome...

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Surviving ICU stay is often just the first step in a long road to recovery for most. The aftermath of critical illness is often challenging for survivors and their caregivers who bear the burden of post-intensive care syndrome (PICS). Unfortunately, there is very little investigation on how...

Ortega-Ribera M, Zhuang Y, Babuta M, Brezani V, Joshi RS, Zsengeller Z, Thevkar Nagesh P, Wang Y, Bronson R, Szabo G. A Novel Multi-organ Male Model of Alcohol-induced Acute-on-chronic Liver Failure Reveals NET-mediated Hepatocellular Death, Which is Prevented by RIPK3 Inhibition. Cell Mol...

Tremor Research Group (TRG) has awarded a grant to develop a new clinical assessment scale for tremor. The project will encompass three sites, BIDMC, University of Texas Southwestern Medical Center and University of Florida and use factor reduction methodologies to develop a new, abbreviated tremor...

Our work in collaboration with Kajimura lab is published in Science. Please check it out: Christopher Auger et al. ,Mitochondrial control of fuel switching via carnitine biosynthesis.Science0,eady5532DOI:10.1126/science.ady5532 https://www.science.org/doi/10.1126/science.ady5532 Congratulations to...

Dr. Bell and Dr. Rodman have a grant from the NIH/National Library of Medicine to design and test an interactive chatbot to help patients read their medical information and prepare for upcoming appointments. Bowdoin St. is partnering with this research team to provide input on what patients -in...

Young adults 18-30 who use cannabis (any type) at least once a week are invited to sign up for SOFTA (Study of Oral Fluid Testing Approach) to see if a saliva test is an accurate way to measure cannabis use. Confidential study activities include surveys, three virtual visits over 2 weeks, and a...

We are pleased to announce a new collaboration between the Flow Cytometry-MassNano Facility and the Precision RNA Medicine Core at BIDMC. This partnership integrates advanced nanoparticle characterization capabilities with lipid nanoparticle (LNP) formulation and production expertise, enabling...

Dr. Heng will have 6 abstracts at AACR: Bockorny et al. Real-world evidence of KMT2C mutation as a biomarker of sensitivity to platinum-based therapy in solid cancers. (Oral) Liu et al. MiR-362-3p enhances platinum response in breast cancer. Guzman-Arocho et al. Associations of Stromal Markers with...