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Our lab focuses on unraveling the biochemistry and neuropathology underlying this complex neurodegenerative disorder. We take a systems-level approach to investigate the molecular mechanisms driving disease progression, particularly focusing on key protein pathways, including VPS35, USP30, LRRK2...

R01; National Institute of Neurological Disorders and Stroke Targeting the FBXW7/PGC1 Pathway as a Therapeutic Strategy for Parkinson's Disease Principal Investigator(s): David K Simon, Wenyi Wei PGC-1alpha regulates mitochondrial synthesis, and a deficiency PGC-1alpha may play a role in Parkinson’s...

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