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Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease | Acta Neuropathologica Communications | Full Text (biomedcentral.com)

Benitez Lab current collaborators include: David Simon, Sam Frank, Lan Luo, Feng Tian, Daniel Press, Stephanie Buss, Subhash Kulkarni, P.A.I.N.T, and the Movement Disorders Center.

The National Institutes of Health (NINDS, NIA) provides funding for projects in our lab. We are also sincerely grateful to the patients, family members, and caregivers who donated their time, brains, and biospecimens for biomedical research. __________________________________________________________...

Niko Nikanen Zhaohua Wang Divya Palanisamy Amelia Li

One of the research interests in our lab is focused on the deep-molecular characterization of a clinically well-defined cohort of patients anchored in genomic data. Alzheimer’s (AD) and Parkinson’s disease (PD) are heterogeneous disorders with identifiable clinical-pathological subtypes based on...

Detailed molecular characterization of cell-specific transcriptomic states throughout multiple brain regions beyond nigrostriatal dopaminergic degeneration will provide mechanistic insights into both motor and non-motor PD symptoms. We will integrate neuropathology and snRNA-Seq data to identify a...