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This project investigated the effects of repeated cycles of short sleep duration on vascular functioning and levels of inflammatory and adhesion molecules in peripheral circulation in healthy participants in order to determine if sleep is essential for homeostasis of multiple host defense mechanisms...

The goal of this study is to test the hypothesis that repeated exposure to cycles of insufficient sleep increases susceptibility to a variety of disease states by progressively compromising the integrity of stress response systems. We will test whether the hypothalamic-pituitary, sympatho-adrenal...

Janet Mullington, PhD Professor of Neurology, Harvard Medical School jmulling@bidmc.harvard.edu Monika Haack, PhD Associate Professor of Neurology, Harvard Medical School mhaack@bidmc.harvard.edu Huan Yang, PhD Instructor of Neurology, Harvard Medical School hyang7@bidmc.harvard.edu

Larissa C. Engert, PhD Postdoctoral Research Fellow, Harvard Medical School lcengert@bidmc.harvard.edu Michael R. Goldstein, PhD Postdoctoral Research Fellow, Harvard Medical School mrgoldst@bidmc.harvard.edu Alicia Stokes, PhD Postdoctoral Research Fellow, Harvard Medical School astokes1@bidmc...

Rammy Dang Research Assistant, Beth Israel Deaconess Medical Center rdang@bidmc.harvard.edu Oscar Yang Research Assistant, Beth Israel Deaconess Medical Center oyang@bidmc.harvard.edu

The Human Sleep and Inflammatory Systems Laboratory at the BIDMC is an international leader in conducting research on the biological basis for the effects of sleep disturbance and deficiency. We utilize intensive physiological monitoring and testing in experimental models of repeated sleep...