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Go to CalR, a web application for indirect calorimetry analysis. The CalR project: There is a critical lack of standardization for indirect calorimetry experiments to measure body composition ( Corrigan et al eLife 2020, Banks et al Nature Metabolism 2025). Currently, the same dataset can produce...

EchoMRI 3-in-1 Body Composition Analyzer Measures live mice up to 100g, tissue samples (including Zebrafish) of 10g, and biopsy samples up to 0.1g Measurements include lean mass, fat mass, and water mass 5 minutes per mouse No anesthesia required

Optogenetic stimulation of Agrp neurons in ChR2-expressing mice was performed in the Promethion calorimeter, with food intake, metabolic rate, body temperature, and activity measured during the stimulation period.

Energy Balance Metabolic Core at BIDMC and Harvard Medical School is a facility designed for the measurement of energy intake, nutritional status, and energy expenditure in experimental mice. CalR Equipment & Technologies Example Experiments

Thermogenesis: cold temperature challenge Thermogenesis: beta-adrenergic agonist activation of mice housed at thermoneutral temperatures Pharmacologic induction of metabolic rate (T3) Diet-induced obesity Optogenetic stimulation of food intake Chemogenetic stimulation of metabolism Induction of...

PARR Instruments Bomb Calorimeter Determines energy content of food or fecal matter FLIR Thermal Imaging Camera Determines thermal radiation

Highly Cited Research from the Core Many discoveries have relied upon careful measurement of body composition and metabolic rates in un-anesthetized, freely moving mice. One metric to determine the impact of a scientific publication is how many times other scientific articles have referred to that...

Sable Systems Promethion Indirect Calorimeter (32 cages) Food intake Water intake In-cage body mass measurement Physical activity (infrared beam breaks) Energy expenditure Oxygen consumption (VO2) Carbon dioxide production (VCO2) Respiratory exchange ratio – an indicator of carbohydrate or fat...

Male C57Bl/6J mice (10–14 weeks, JAX) were monitored in the Promethion indirect calorimeter at 30°C, 23°C, and 4°C, tracking body weight and energy expenditure, with data analyzed in CalR. ​

C57Bl/6J male mice were monitored in the Promethion indirect calorimeter, and data were analyzed in CalR to compare energy expenditure between T3-treated and vehicle groups (Hochbaum et al., Cell, 2024).