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Zeidel Lab

Zeidel Lab, BIDMC, Harvard Medical School, Dr. Mark Zeidel, Mark Zeidel Lab, Incontinence, Overactive Bladder, Bladder Pain and Lower Urinary Tract, Kidney, Kidney Research in BIDMC, Bladder Research in BIDMC, Basic Cellular Mechanisms Underlying Diseases of the Lower Urinary Tract, Benign Urology Research, Warren Hill, Bryce MacIver, John Mathai, Weiqun Yu

Delighted to announce Dr. Verstegen's selection as a keynote speaker for the CAIRIBU Annual Meeting

News: November 19, 2025

The title of her talk is " Neuronal populations of Barrington’s nucleus and their specialized roles in lower urinary tract function"

Alumni

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Name Date Current Position Ali Wu, MD Erandi Velaquez-Miranda, PhD Lian Yu Guo, PhD Reina Kobayashi, DVM

Results

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Results - Obtained Under Urethane Anesthesia Regions that show activation during CMG peak include the Pontine Micturition Center (PMC), the Periaqueductal Gray (PAG) and the Hypothalamus. The PMC is a small center in the hindbrain that we now know activates bladder contractions, whereas the PAG...

A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease.

Publication: Journal Article

Aron, Liviu, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A Fernandez, et al. 2023. “A Neurodegeneration Checkpoint Mediated by REST Protects Against the Onset of Alzheimer’s Disease.”. Nature Communications 14 (1): 7030.

Minimizing the variables of voiding spot assay for comparison between laboratories.

Publication: Journal Article

Luo, Chuang, Juan Liu, Jiali Yang, Xiang Xie, Weiqun Yu, and Huan Chen. 2023. “Minimizing the Variables of Voiding Spot Assay for Comparison Between Laboratories.”. PeerJ 11: e15420.

Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study.

Publication: Journal Article

Raines, Nathan H, Sarju Ganatra, Pitchaphon Nissaisorakarn, Amar Pandit, Alex Morales, Aarti Asnani, Mehrnaz Sadrolashrafi, et al. 2021. “Niacinamide May Be Associated With Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study.”. Kidney360 2 (1): 33-41.

Novel peptidomimetic compounds attenuate hypoxic-ischemic brain injury in neonatal rats.

Publication: Journal Article

Chen, Xiaodi F, Brynn Kroke, Jun Ni, Christian Munoz, Mark Appleman, Bryce Jacobs, Tuong Tran, et al. 2025. “Novel Peptidomimetic Compounds Attenuate Hypoxic-Ischemic Brain Injury in Neonatal Rats.”. Experimental Neurology 386: 115151.

Single Cell RNA-seq Identification of Neuron Populations Controlling Bladder Function

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Modern transgenic “tools” enable specific neuron populations to be mapped, monitored, and manipulated in vivo. While these approaches represent an enormous advance, their application requires knowledge of specific transcriptional markers for distinguishing the neurons of interest from their...

Yu lab presents recent research at the SUFU Winter meeting

News: February 26, 2025

This years Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU) Winter Meeting was held in sunny California at the Westin Rancho Mirage Golf Resort and Spa. Dr Sagar Barge presented his poster entitled; ‘Role of Insulin Signaling in Bladder Smooth Muscle Cell...