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Orexin neurons inhibit sleep to promote arousal

Publication: Journal

De Luca, Roberto, Stefano Nardone, Kevin P. Grace, Anne Venner, Michela Cristofolini, Sathyajit S. Bandaru, Lauren T. Sohn, et al. 2022. “Orexin Neurons Inhibit Sleep to Promote Arousal”. https://doi.org/10.1038/s41467-022-31591-y.

Defining disrupted nighttime sleep and assessing its diagnostic utility for pediatric narcolepsy type 1

Publication: Journal

Maski, Kiran P, Fabio Pizza, Shanshan Liu, Erin Steinhart, Elaina Little, Alicia Colclasure, Cecilia Diniz Behn, et al. 2020. “Defining Disrupted Nighttime Sleep and Assessing Its Diagnostic Utility for Pediatric Narcolepsy Type 1”. https://doi.org/10.1093/sleep/zsaa066.

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Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1

Publication: Journal

“Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1”. 2023. https://doi.org/10.1056/NEJMoa2301940.

Catching Up on REMs

Publication: Journal

Burgess, Christian R., and Thomas E. Scammell. 2022. “Catching Up on REMs”. https://doi.org/10.1056/NEJMcibr2203101.

Clinical considerations for the diagnosis of idiopathic hypersomnia

Publication: Journal

Dauvilliers, Yves, Richard K. Bogan, Isabelle Arnulf, Thomas E. Scammell, Erik K. St Louis, and Michael J. Thorpy. 2022. “Clinical Considerations for the Diagnosis of Idiopathic Hypersomnia”. https://doi.org/10.1016/j.smrv.2022.101709 Free article.

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

Publication: Journal

Xiao, Xing, Gagik Yeghiazaryan, Simon Hess, Paul Klemm, Anna Sieben, Andre Kleinridders, Donald A. Morgan, et al. 2021. “Orexin Receptors 1 and 2 in Serotonergic Neurons Differentially Regulate Peripheral Glucose Metabolism in Obesity”. https://doi.org/10.1038/s41467-021-25380-2.

Research

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1. Cataplexy is generally triggered by strong, positive emotions such as those that occur when laughing at a great joke or playing with a friend. The amygdala is a key site through which emotions trigger motor responses, and we are working to identify just which neurons in the amygdala mediate...