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Mitochondrial DNA mutations in Parkinson's disease brain
Simon, David K, Joanne Clark Matott, Janaina Espinosa, and Neeta A Abraham. 2017. “Mitochondrial DNA Mutations in Parkinson’s Disease Brain”. Acta Neuropathol Commun.
Our Team
Alejandra and Emily dive into research discussions during an engaging poster session
PGC-1α
Simon Lab: Lunchtime Science Chatter After a Successful Poster Presentation
Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease
Clark, Joanne, Sonika Reddy, Kangni Zheng, Rebecca A Betensky, and David K Simon. 2011. “Association of PGC-1alpha Polymorphisms With Age of Onset and Risk of Parkinson’s Disease”. BMC Med Genet.
Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation
Dai, Ying, Kangni Zheng, Joanne Clark, Russell H Swerdlow, Stefan M Pulst, James P Sutton, Leslie A Shinobu, and David K Simon. 2013. “Rapamycin Drives Selection Against a Pathogenic Heteroplasmic Mitochondrial DNA Mutation”. Hum Mol Genet.
Our Scientific Approach
Our lab focuses on unraveling the biochemistry and neuropathology underlying this complex neurodegenerative disorder. We take a systems-level approach to investigate the molecular mechanisms driving disease progression, particularly focusing on key protein pathways, including VPS35, USP30, LRRK2...
Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease
Lin, Michael T, Ippolita Cantuti-Castelvetri, Kangni Zheng, Katie E Jackson, Yong B Tan, Thomas Arzberger, Andrew J Lees, Rebecca Betensky, Flint Beal, and David K Simon. 2012. “Somatic Mitochondrial DNA Mutations in Early Parkinson and Incidental Lewy Body Disease”. Ann Neurol.