Search

Search results

22 results found

Peripheral Biomarkers of Parkinson's Disease Progression and Pioglitazone Effects.

Publication: Journal Article

Simon, DK, T Simuni, J Clark-Matott, AK Graebner, L Baker, SR Dunlop, M Emborg, et al. 2015. “Peripheral Biomarkers of Parkinson’s Disease Progression and Pioglitazone Effects.”. Journal of Parkinson’s Disease.

LRRK2 and Rab proteins

Page

Leucine-rich repeat kinase 2 (LRRK2) is a critical protein associated with the pathogenesis of Parkinson's disease (PD), particularly through its influence on the endolysosomal system and the clearance of alpha-synuclein (aSyn) aggregates. The G2019S mutation in LRRK2 is the most prevalent...