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2024 BIDMC Annual Research Retreat

News: September 05, 2024

Simon Lab members attended the research retreat. Alejandra and Emily presented "Pharmacological stabilization of the retromer complex results in the reduction of α-synuclein accumulation and in the control of α-synuclein clearance pathways" and joined in conversations about the latest research at...

Instructor in Neurology Dr. Simona Eleuteri showcased her work on neuroprotection in PD mouse models at the 2022 SfN annual meeting in San Diego.

News: November 11, 2022

PGC-1α

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Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

Publication: Journal Article

XS, Ding, Gao L, Han Z, Shi W, Shen Y, Song ZY, Su M, et al. 2023. “Ferroptosis in Parkinson’s Disease: Molecular Mechanisms and Therapeutic Potential”. Ageing Research Reviews.

Our Team

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Sphingolipid and Phospholipid Levels Are Altered in Human Brain in Chorea-Acanthocytosis

Publication: Journal Article

Ditzel, RM, RH Walker, MJ Nirenberg, AM Tetlow, K Farrell, KJ Lind-Watson, EL Thorn, et al. 2023. “Sphingolipid and Phospholipid Levels Are Altered in Human Brain in Chorea-Acanthocytosis”. Movement Disorders.

PGC-1α regulation by FBXW7 through a novel mechanism linking chaperone-mediated autophagy and the ubiquitin-proteasome system

Publication: Journal Article

Eleuteri, Simona, Bao Wang, Gianni Cutillo, Tracy Shi Zhang Fang, Kai Tao, Yan Qu, Qian Yang, Wenyi Wei, and David K Simon. 2024. “PGC-1α Regulation by FBXW7 through a Novel Mechanism Linking Chaperone-Mediated Autophagy and the Ubiquitin-Proteasome System”. The FEBS Journal.

USP30

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Efficacy of Deep Brain Stimulation in a Patient with Genetically Confirmed Chorea-Acanthocytosis

Publication: Journal Article

Richard, Alby, Joey Hsu, Patricia Baum, Ron Alterman, and David K. Simon. 2019. “Efficacy of Deep Brain Stimulation in a Patient With Genetically Confirmed Chorea-Acanthocytosis”. Case Reports in Neurology.

VPS35 and mitochondria: Connecting the dots in Parkinson's disease pathophysiology

Publication: Journal Article

Cutillo, G, DK Simon, and S Eleuteri. 2020. “VPS35 and Mitochondria: Connecting the Dots in Parkinson’s Disease Pathophysiology”. Neurobiology of Disease.