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Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver.

Publication: Journal Article

Babuta, Mrigya, Prashanth Thevkar Nagesh, Aditi Ashish Datta, Victoria Remotti, Yuan Zhuang, Jeeval Mehta, Francesca Lami, Yanbo Wang, and Gyongyi Szabo. 2024. “Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver.”. Cells 13 (11).

Reply: How does bile acid-induced IRF3 phosphorylation mediate cholestatic liver and kidney injury?-More needs to be known.

Publication: Journal Article

Zhuang, Yuan, and Gyongyi Szabo. 2024. “Reply: How Does Bile Acid-Induced IRF3 Phosphorylation Mediate Cholestatic Liver and Kidney Injury?-More Needs to Be Known.”. Hepatology (Baltimore, Md.) 80 (1): E2-E3.

Acute kidney injury in severe alcohol-associated hepatitis treated with anakinra plus zinc or prednisone.

Publication: Journal Article

Patidar, Kavish R, Wanzhu Tu, Thomas G Cotter, Douglas A Simonetto, Amon Asgharpour, Muhammad Y Jan, Qing Tang, et al. 2024. “Acute Kidney Injury in Severe Alcohol-Associated Hepatitis Treated With Anakinra Plus Zinc or Prednisone.”. Hepatology (Baltimore, Md.).

In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis.

Publication: Journal Article

Nagesh, Prashanth Thevkar, Yeonhee Cho, Yuan Zhuang, Mrigya Babuta, Martí Ortega-Ribera, Radhika Joshi, Veronika Brezani, et al. 2024. “In Vivo Bruton’s Tyrosine Kinase Inhibition Attenuates Alcohol-Associated Liver Disease by Regulating CD84-Mediated Granulopoiesis.”. Science Translational Medicine 16 (759): eadg1915.

Associate - Clinical Research / Research

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Inflammation in NASH

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Danger signals and pathways of macrophage activation in NASH Inflammatory cell activation drives diverse cellular programming in steatohepatitis. Our studies revealed that activation of the multiprotein complex, inflammasome, contributes to non-alcoholic steatohepatitis (NASH) involving the NLRP3...

NIH/NIAAA - Innate Immune Signaling in Alcoholic Liver Disease – Alzheimer’s Disease Supplement:

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Experiments proposed in this supplement will explore novel signaling molecules in alcohol-induced neuroinflammation and interactions between alcohol use and key pathways in the biology of neuroinflammation and AD dementia. Our studies will reveal new potential therapeutic targets in the dual insult...

Instructors

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Szabo Lab invites applications for Clinical Researcher (volunteer role)

News: April 30, 2024

Scott Minchenberg, MD PhD

Person: Clinical Fellow in Gastroenterology & Hepatology, Postdoctoral Research Fellow

My goal as a physician scientist is to gain insights in interplay between macronutrients, cellular metabolism, and inflammation. Specifically, I am focused on the impact of alcohol on Gastrointestinal (GI) mucosal immunity. Immune dysregulation in the GI mucosa has been implicated in the...