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NIH/NIAAA - Innate Immune Signaling in Alcoholic Liver Disease – Alzheimer’s Disease Supplement:

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Experiments proposed in this supplement will explore novel signaling molecules in alcohol-induced neuroinflammation and interactions between alcohol use and key pathways in the biology of neuroinflammation and AD dementia. Our studies will reveal new potential therapeutic targets in the dual insult...

Szabo Lab invites applications for Clinical Researcher (volunteer role)

News: April 30, 2024

Scott Minchenberg, MD PhD

Person: Clinical Fellow in Gastroenterology & Hepatology, Postdoctoral Research Fellow

My goal as a physician scientist is to gain insights in interplay between macronutrients, cellular metabolism, and inflammation. Specifically, I am focused on the impact of alcohol on Gastrointestinal (GI) mucosal immunity. Immune dysregulation in the GI mucosa has been implicated in the...

Viliam Brezani, PhD

Person: Research Asistant II

Prashanth Thevkar Nagesh, PhD

Person: Instructor

Prashanth is studying immunophenotyping of PBMCs from alcoholic hepatitis patients and their functional profiling in response to PAMPs.

Gyongyi Szabo

Person: Principal Investigator

Add blurb here https://connects.catalyst.harvard.edu/Profiles/display/Person/28770

Yeshaswini Katkoori

Person:

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Instructors

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Gut-Liver Axis and Acute-on-Chronic Liver Failure (ACLF)

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Gut-Liver Axis Excessive alcohol consumption results in GI tract dysfunction including disruption of the intestinal barrier and exposure of the liver to microbes and gut-derived pathogen-associated molecular patterns (PAMPs). The upper GI tract is exposed to the highest amount of alcohol but little...

Steatohepatitis - MASH/MetALD and Inflammation

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Danger signals and pathways of macrophage activation in MASH Inflammatory cell activation drives diverse cellular programming in steatohepatitis. Our studies revealed that activation of the multiprotein complex, inflammasome, contributes to metabolic dysfunction associated steatohepatitis (MASH)...