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Macrophages (MØ), Kupffer cells (KC), and neutrophils mediate inflammation and play an important role in the pathogenesis of alcohol-associated liver disease (ALD). Previous studies have demonstrated the damaging effects of pro-inflammatory macrophages on alcoholic liver inflammation and high...

Alcoholic Hepatitis Clinical and Translational Network Late Phase Clinical Trials and Observational Studies Alcoholic liver disease (ALD) is a major cause of liver-related morbidity and mortality in the US. Alcoholic hepatitis (AH) is a life-threatening form of ALD. Severe AH is associated with a...

Experiments proposed in this supplement will explore novel signaling molecules in alcohol-induced neuroinflammation and interactions between alcohol use and key pathways in the biology of neuroinflammation and AD dementia. Our studies will reveal new potential therapeutic targets in the dual insult...

Gut-Liver Axis Excessive alcohol consumption results in GI tract dysfunction including disruption of the intestinal barrier and exposure of the liver to microbes and gut-derived pathogen-associated molecular patterns (PAMPs). The upper GI tract is exposed to the highest amount of alcohol but little...

Danger signals and pathways of macrophage activation in MASH Inflammatory cell activation drives diverse cellular programming in steatohepatitis. Our studies revealed that activation of the multiprotein complex, inflammasome, contributes to metabolic dysfunction associated steatohepatitis (MASH)...