Frankie Heyward identifies IRF3 as a key mediator of the acute hunger-suppressing effects of leptin in AgRP neurons
Frankie Heyward’s paper was just published in Nature Communications. Frankie used cell-type specific profiling of gene expression and chromatin state in AgRP neurons to predict novel transcriptional mediators of leptin action. Surprisingly, his data suggested that IRF3 might work downstream of...