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A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance.

Publication: Journal Article

Jun, Lucy S, Parker Siddall, and Evan D Rosen. 2011. “A Minor Role for Lipocalin 2 in High-Fat Diet-Induced Glucose Intolerance.”. American Journal of Physiology. Endocrinology and Metabolism 301 (5): E825-35.

The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance.

Publication: Journal Article

Yan, Qing-Wu, Qin Yang, Nimesh Mody, Timothy E Graham, Chung-Hsin Hsu, Zhao Xu, Nicholas E Houstis, Barbara B Kahn, and Evan D Rosen. 2007. “The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance.”. Diabetes 56 (10): 2533-40.

Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to exogenous steroids, but not insulin resistance caused by high fat feeding.

Publication: Journal Article

Shen, Yachen, Hyun Cheol Roh, Manju Kumari, and Evan D Rosen. 2017. “Adipocyte Glucocorticoid Receptor Is Important in Lipolysis and Insulin Resistance Due to Exogenous Steroids, But Not Insulin Resistance Caused by High Fat Feeding.”. Molecular Metabolism 6 (10): 1150-60.

Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin’s hunger-suppressing effects

Publication: Unpublished

Heyward, Frankie D., Nan Liu, Christopher Jacobs, Rachael Ivison, Natalia Machado, Aykut Uner, Harini Srinivasan, et al. 2022. “Integrated Genomic Analysis of AgRP Neurons Reveals That IRF3 Regulates Leptin’s Hunger-Suppressing Effects”. BioRxiv.

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Greg Westcott

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Frankie Heyward starts his own lab at UT Southwestern Medical Center

News: September 19, 2023

Frankie Heyward is starting his own lab in Dallas, Texas! Frankie is an Assistant Professor of Internal Medicine and Neuroscience at UT Southwestern Medical Center, and he is joining the Center for Hypothalamic Research. Best wishes, Frankie!

Welcome, Yangmian!

News: March 11, 2024

We are delighted to welcome our newest team member, Yangmian Yuan, who joins us as a postdoctoral research fellow. Yangmian recently earned her PhD from the College of Life Sciences at Wuhan University, China, with a dissertation focusing on adipose tissue energy metabolism.

Evan Rosen publishes a new review article on interferon regulatory factors (IRFs) in metabolism

News: May 20, 2024

Evan wrote a comprehensive review article on interferon regulatory factors (IRFs) in metabolism, with help from Zunair Ahmad and Wahab Kahloan. It just came out in Nature Reviews Endocrinology.

Shuai Yan reveals interferon regulatory factor 3 (IRF3) crucial for inflammation and insulin resistance

News: May 30, 2024

Congratulations to Shuai Yan — his paper was just published in Nature Communications. Shuai showed that IRF3 causes insulin resistance in adipocytes independent of any effect on body weight. The mechanism is via induction of an enzyme called AIG1, which encodes a hydrolase that destroys insulin...