BIDMC Mass Spectrometry Core Enables Discovery of TRIDENT, a New Driver of Drug Resistance in Lung Cancer
A recent PNAS publication from Dr. Frank Slack’s group uncovers TRIDENT, an EGFR-induced long non-coding RNA that plays a key role in tumor growth and chemoresistance in non–small cell lung cancer (NSCLC). The team shows that TRIDENT activates TRIM28-mediated DNA damage repair, allowing cancer cells...