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Sugar-binding and split domain combinations in repeats-in-toxin adhesins from Vibrio cholerae and Aeromonas veronii mediate cell-surface recognition and hemolytic activities.

Publication: Journal Article

Sherik, Mustafa, Robert Eves, Shuaiqi Guo, Cameron J Lloyd, Karl E Klose, and Peter L Davies. 2024. “Sugar-Binding and Split Domain Combinations in Repeats-in-Toxin Adhesins from Vibrio Cholerae and Aeromonas Veronii Mediate Cell-Surface Recognition and Hemolytic Activities.”. MBio 15 (2): e0229123.

The restricted N-glycome of neurons is programmed during differentiation.

Publication: Journal Article

Kiwimagi, Katherine, Maxence Noel, Murat Cetinbas, Ruslan I Sadreyev, Lei Wang, Jordan W Smoller, Richard D Cummings, Ron Weiss, and Robert G Mealer. 2024. “The Restricted N-Glycome of Neurons Is Programmed During Differentiation.”. BioRxiv : The Preprint Server for Biology.

Direct Binding Assay + MAWE Protocol

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1. Introduction 1.1 Primary objective is to determine the binding specificity of directly labeled Glycan Binding Proteins (GBPs) submitted by investigators. The primary array platform is the CFG printed defined glycan microarray. Subsequently, remove binding using the MAWE method for future reuse of...

Glycan Binding Assay with Biotin-tagged Sample + MAWE

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1. Introduction: 1.1. Primary objective is to determine the binding specificity of Glycan Binding Proteins (GBPs) and organisms submitted by investigators, using the printed glycan microarray platform. Removal of binding with the MAWE method, for future reuse of the slide. 2. References: 2.1. https...

Unlabeled Monoclonal Antibody + MAWE

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1. Introduction: 1.1. Primary objective is to determine the binding specificity of a Monoclonal Antibody submitted by investigators, using the printed glycan microarray, and removing with MAWE protocol for reusability. 2. Reference: 2.1. https://research.bidmc.org/ncfg 2.2. Akul Y Mehta, Catherine A...

A glycan atlas of the mammalian intestine through ontogeny and inflammation.

Publication: Journal Article

Siegel, Steven J, Daniel Pomerantz, Jamie Heimburg-Molinaro, Shaikh Danish Mahmood, Joshua R Korzenik, Richard D Cummings, and Seth Rakoff-Nahoum. 2025. “A Glycan Atlas of the Mammalian Intestine through Ontogeny and Inflammation.”. BioRxiv : The Preprint Server for Biology.

21] Facts About: Intracellular Protein Glycosylation

Blog: October 06, 2025

By: Richard D. Cummings In the mid 1980s it was strongly believed that all glycosylated proteins arose within the secretory pathway, which generated both secreted and membrane-bound (plasma membrane) glycoproteins. This accepted process was taken to indicate that no glycosylated proteins occurred in...

22] Facts About: X-linked Glyco-Related Genes

Blog: November 03, 2025

By: Richard D. Cummings Among the 900-1,400 genes on the human X chromosome (1, 2) [1], there are many genes important in the metabolism of glycomolecules, including glycosyltransferases, glycohydrolases, transporters, and chaperones. Mutations in several of these X-linked genes, either heritable or...

17] Facts About: Two Tiny Glycolipids – Essential to Life

Blog: March 24, 2025

By: Richard D. Cummings Glycosphingolipids (GSLs) are sphingolipids, such as ceramide, to which sugars are linked. They are found in virtually all organisms including bacteria, fungi, plants, and animals (1), and many different human and animal parasites (2). Sphingolipids were originally discovered...

Plant-Produced Therapeutic Crizanlizumab Monoclonal Antibody Binds P-Selectin to Alleviate Vaso-occlusive Pain Crises in Sickle Cell Disease.

Publication: Journal Article

Yang, Taewon, Hyunjoo Hwang, Kibum Kim, Yerin Kim, Richard D Cummings, Yong Kyoo Shin, Taejin Lee, and Kisung Ko. 2025. “Plant-Produced Therapeutic Crizanlizumab Monoclonal Antibody Binds P-Selectin to Alleviate Vaso-Occlusive Pain Crises in Sickle Cell Disease.”. Molecular Biotechnology 67 (3): 834-44.