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Identification and Characterization of Circulating Immune Complexes in IgA Nephropathy

News: October 29, 2022

Co-First Authors: Yasuyuki Matsumoto and Rajindra P Aryal Senior/Corresponding Author: Richard D Cummings, Professor, Dept. of Surgery, BIDMC/Harvard Medical School Published in Science Advances, October 28, 2022 A breakthrough in our understanding the human disease called IgA Nephropathy, has just...

Research

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The “ National Center for Functional Glycomics” ( NCFG) as a National Resource Center is devoted to the technology of glycan recognition through microarray display and other modes of glycan presentation. This Center is the first of its kind with the central focus being exploration of the functional...

Technology Research and Development (TR&Ds)

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The NCFG operates under 3 TR&D projects: Project 1 – Expansion of Glycan Microarray Technology Project 2 – Shotgun Glycomics and Functional Recognition Project 3 – Glycan Display and Recognition TR&D project goals will focus on 5 main areas and the projects integrates and synergizes with each other...

Annual AAI meeting- Immunology 2017

Events: Thursday, May 11, 2017, 08:00pm -Monday, May 15, 2017, 08:00pm

Visit http://www.immunology2017.org/ Special Guest Society Symposium by the Society for Glycobiology (SfG): Emerging Roles for Glycans in Immunity and Novel Tools to Understand Them

Glycoprotein N-glycan preparation for MS analysis

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Goal: To prepare glycoproteins for N-glycan isolation and analysis by mass spectrometry. Notes: Glassware and glass tubes are cleaned with MilliQ water and dried beforehand. Reagents are weighted on aluminum foil with utensils cleaned with MilliQ water beforehand. Whenever possible, liquid reagents...

Glycan Binding Assay with Unlabeled Monoclonal Antibody

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1. Introduction: 1.1.Primary objective is to determine the binding specificity of a Monoclonal Antibody submitted by investigators, using the printed glycan microarray. 2. Reference: 2.1. www.functionalglycomics.org 3. Materials needed: 3.1.Glycan printed slides , printed on the side of the slide...

2] Facts About: The Smallest and the Largest Glycoproteins in Mammals

Blog: December 01, 2023

By: Richard D. Cummings One of the smallest known naturally-occurring glycoprotein in mammals is likely to be CD24, also known as nectadrin. Although it behaves in analyses as a 23-60 kDa glycoprotein, the glycoprotein from mice has only 27 amino acids (human protein has 30 amino acids) (1-3)...

3] Facts About: Pectin – One of the Most Complex Polysaccharides in Nature and its Healing Properties

Blog: January 01, 2024

By: Richard D. Cummings One of the most complex polysaccharides in nature is pectin, found in plant cell walls (1,2). Pectin is a family of galacturonic acid-rich polysaccharides that includes homogalacturonan (HG), rhamnogalacturonan I (RG-I), and the substituted galacturonans rhamnogalacturonan II...

13] Facts About: Bacterial Cellulose

Blog: November 06, 2024

By: Richard D. Cummings While plant cellulose is very famous, many commercial products containing cellulose actually use bacterial cellulose. It is often a part of bacterial biofilms, typically of Gram negative (1). This form of cellulose can be highly purified compared to preparations of plant...

14] Facts About: Keyhole Limpet Hemocyanin (KLH) and its Unusual Glycosylation

Blog: December 05, 2024

By: Richard D. Cummings One of the most unusual glycoproteins and one used commonly in biological research and immunology is KLH, which is derived from the giant keyhole limpet ( Megathura crenulata). The keyhole limpet is a giant aquatic snail (gastropod) with a cone-shaped shell (shell length can...