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We found that lin-4 mutants have short lifespans, while lin-4 over-expression extends lifespan and slows aging [1]. This was the first report of a role for miRNAs in regulating lifespan, and led to an intense study in my lab of roles for miRNAs in aging. Initially, we performed high throughput...

Latika Matai, PhD Latika is from New Delhi, India where she pursued her doctoral research studying aging, dietary restriction and stress responses using C. elegans as the model organism. She moved to United States in 2017 and later joined the Slack lab in 2019. She is interested in investigating the...

Tanvi Saxena (Harvard BBS Program) Tanvi grew up in New Delhi, India and graduated from the Indian Institute of Technology, Delhi with a B.Tech and M.Tech in Biochemical Engineering and Biotechnology. Having always been interested in the biological sciences and disease focused research, she worked...

NIH/NIA- JUVENILE MICRORNAS PROMOTING HEALTHIER ADULT AGING: We showed first that microRNAs control aging and that they act upstream of insulin and insulin-like receptor (IIS) and other known longevity pathways. In this proposal, we propose to use discovery-based and hypothesis-based methods that we...

Mis-regulation of genes that control cell proliferation and cell fate determination often contribute to cancer development. In C. elegans let-7 mutants, stem cells frequently fail to terminally differentiate, and instead elect to divide again, a hallmark of cancer [7]. In C. elegans, let-7 directly...

Francisca Lamini Francisca is a sophomore at Harvard College studying molecular and Cellular biology with a secondary in global health and health policy. She is also on the premed track. Ellie Shin Ellie is a junior at Harvard College studying Biomedical Engineering with a Language Citation in...

Name Dates Current Position Jihoon Lim 2018-2020 Medical School Student, University of Central Florida Bohyung Yoon 2015-2018 Stacy Piccirillo 2009-2010 Xianping Liang 2007-2011 Kristy Reinert 2002-2004 Shin-Yi Lin 2001-2003 Carol Bascom-Slack 2000

Since miRNAs bind to imperfect complementary sequences in the 3’UTR of target mRNAs to repress target gene expression [3, 4] [1, 2, 5-9], the 3’UTR has rightly received increased interest recently. A new insight into cancer biology has come with the finding that functional single nucleotide...