Architecture of a validated microRNA::target interaction.
Vella, Monica C, Kristy Reinert, and Frank J Slack. 2004. “Architecture of a Validated MicroRNA::Target Interaction.”. Chemistry & Biology 11 (12): 1619-23.
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The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR.
Vella, Monica C, Eun-Young Choi, Shin-Yi Lin, Kristy Reinert, and Frank J Slack. 2004. “The C. Elegans MicroRNA Let-7 Binds to Imperfect Let-7 Complementary Sites from the Lin-41 3’UTR.”. Genes & Development 18 (2): 132-7.
The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter.
Johnson, Steven M, Shin Yi Lin, and Frank J Slack. 2003. “The Time of Appearance of the C. Elegans Let-7 MicroRNA Is Transcriptionally Controlled Utilizing a Temporal Regulatory Element in Its Promoter.”. Developmental Biology 259 (2): 364-79.
The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target.
Lin, Shin-Yi, Steven M Johnson, Mary Abraham, Monica C Vella, Amy Pasquinelli, Chiara Gamberi, Ellen Gottlieb, and Frank J Slack. 2003. “The C Elegans Hunchback Homolog, Hbl-1, Controls Temporal Patterning and Is a Probable MicroRNA Target.”. Developmental Cell 4 (5): 639-50.
Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression.
Lee, Soo Mi, Christopher L Avalos, Christos Miliotis, Hanna M Doh, Erica Chan, Kenneth M Kaye, and Frank J Slack. 2025. “Host MicroRNA-31-5p Represses Oncogenic Herpesvirus Lytic Reactivation by Restricting the RNA-Binding Protein KHDRBS3-Mediated Viral Gene Expression.”. BioRxiv : The Preprint Server for Biology.
Slack Lab
Slack Lab, Frank Slack Lab, RNA research lab in BIDMC, The Slack Lab is at the forefront of the small RNA revolution, we co-discovered the second known miRNA and the first human miRNA. Non-coding RNAs in Basic and Translational Research,
tRNA modifications are required for stress granule formation and melanoma metastasis.
Hughes, Riley O, Hannah J Davis, Leona A Nease, Paul Zumbo, Mauro Danielli, Wyatt Tran, Kilian Maidhof, et al. 2025. “TRNA Modifications Are Required for Stress Granule Formation and Melanoma Metastasis.”. BioRxiv : The Preprint Server for Biology.
MiRNA-Binding Site Polymorphisms, Cancer Risk and Outcome
Since miRNAs bind to imperfect complementary sequences in the 3’UTR of target mRNAs to repress target gene expression [3, 4] [1, 2, 5-9], the 3’UTR has rightly received increased interest recently. A new insight into cancer biology has come with the finding that functional single nucleotide...
Post Docs
Name Dates Current Position Maud-Emmanuelle Gilles 2016-2019 Study Director in Preclinical Department, Namsa, France Leni Jacob 2015-2018 Senior Research Scientist, The RNA Medicines Company, Cambridge, Massachusetts Eleni Anastasiadou 2014-2018 Instructor, La Sapienza University, Rome. Rajesha...
miR-155 as a novel clinical target for hematological malignancies.
Witten, Lisa, and Frank J Slack. 2020. “MiR-155 As a Novel Clinical Target for Hematological Malignancies.”. Carcinogenesis 41 (1): 2-7.