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Impedit aliquid quas asperiores similique et. Dolores minus non qui deserunt. Sit Minima Eveniet Iusto Error. Quaerat eligendi occaecati nesciunt totam totam. Est ut commodi officiis. Dolor minus illo. Magnam eaque rerum suscipit sequi quae quisquam possimus. Rerum ipsum harum. Ea esse quis...

Welcome our summer intern student!

News: June 17, 2024

We welcome Solomon to our lab for the summer internship program at the Center for Drug Discovery and Translational Research, BIDMC, Harvard Medical School. Our competitive 3-month internship program is designed to provide outstanding undergraduate students with hands-on laboratory experience in drug...

Anh-Tuan is attending Gordon Research Seminar and Conference

News: August 10, 2024

Anh-Tuan will attend Gordon Research Seminar and Conference in Medicinal Chemistry (August 10 - 16). He'll present our research in AHR modulators. Please stop by Anh-Tuan's poster to learn more about our exciting research!

Discovery of selective Orai channel blockers bearing an indazole or a pyrazole scaffold

Publication: Journal Article

Liardo, Elisa, Anh-Tuan Pham, Amanda F. Ghilardi, Tetyana Zhelay, Kalina Szteyn, Naga Lakshmi Gandi, Anil Ekkati, Steffi Koerner, Ashot Kozak, and Lijun Sun. 2024. “Discovery of Selective Orai Channel Blockers Bearing an Indazole or a Pyrazole Scaffold”. European Journal of Medicinal Chemistry 278: 116805.

Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers.

Publication: Journal Article

Bai, Sha, Masazumi Nagai, Steffi K Koerner, Aristidis Veves, and Lijun Sun. 2017. “Structure-Activity Relationship Study and Discovery of Indazole 3-Carboxamides As Calcium-Release Activated Calcium Channel Blockers.”. Bioorganic & Medicinal Chemistry Letters 27 (3): 393-97.

Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation.

Publication: Journal Article

Wang, Yiqiang, Andreas Hedblom, Steffi K Koerner, Mailin Li, Finith E Jernigan, Barbara Wegiel, and Lijun Sun. 2016. “Novel Synthetic Chalcones Induce Apoptosis in the A549 Non-Small Cell Lung Cancer Cells Harboring a KRAS Mutation.”. Bioorganic & Medicinal Chemistry Letters 26 (23): 5703-6.

Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo.

Publication: Journal Article

Krishnamurthy, Venkata R, Mohammed Y R Sardar, Yu Ying, Xuezheng Song, Carolyn Haller, Erbin Dai, Xiaocong Wang, et al. 2015. “Glycopeptide Analogues of PSGL-1 Inhibit P-Selectin in Vitro and in Vivo.”. Nature Communications 6: 6387.

Research

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Blog: May 08, 2024

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Blog: May 08, 2024

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