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Genetic ablation of FASN attenuates the invasive potential of prostate cancer driven by Pten loss.

Publication: Journal Article

Bastos, Débora C, Caroline F Ribeiro, Thomas Ahearn, Jéssica Nascimento, Hubert Pakula, John Clohessy, Lorelei Mucci, et al. 2021. “Genetic Ablation of FASN Attenuates the Invasive Potential of Prostate Cancer Driven by Pten Loss.”. The Journal of Pathology 253 (3): 292-303.

Cabozantinib Unlocks Efficient In Vivo Targeted Delivery of Neutrophil-Loaded Nanoparticles into Murine Prostate Tumors.

Publication: Journal Article

Chaudagar, Kiranj Kishor, Natalie Landon-Brace, Aniruddh Solanki, Hanna M Hieromnimon, Emma Hegermiller, Wen Li, Yue Shao, et al. 2021. “Cabozantinib Unlocks Efficient In Vivo Targeted Delivery of Neutrophil-Loaded Nanoparticles into Murine Prostate Tumors.”. Molecular Cancer Therapeutics 20 (2): 438-49.

Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.

Publication: Journal Article

Nachmani, Daphna, Anne H Bothmer, Silvia Grisendi, Aldo Mele, Dietmar Bothmer, Jonathan D Lee, Emanuele Monteleone, et al. 2019. “Germline NPM1 Mutations Lead to Altered RRNA 2’-O-Methylation and Cause Dyskeratosis Congenita.”. Nature Genetics 51 (10): 1518-29.

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer.

Publication: Journal Article

Ali, Azhar, Elena Levantini, Jun Ting Teo, Julian Goggi, John G Clohessy, Chan Shuo Wu, Leilei Chen, et al. 2018. “Fatty Acid Synthase Mediates EGFR Palmitoylation in EGFR Mutated Non-Small Cell Lung Cancer.”. EMBO Molecular Medicine 10 (3).

Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.

Publication: Journal Article

Bezzi, Marco, Nina Seitzer, Tomoki Ishikawa, Markus Reschke, Ming Chen, Guocan Wang, Caitlin Mitchell, et al. 2018. “Diverse Genetic-Driven Immune Landscapes Dictate Tumor Progression through Distinct Mechanisms.”. Nature Medicine 24 (2): 165-75.

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Publication: Journal Article

Matsumoto, Akinobu, Alessandra Pasut, Masaki Matsumoto, Riu Yamashita, Jacqueline Fung, Emanuele Monteleone, Alan Saghatelian, Keiichi I Nakayama, John G Clohessy, and Pier Paolo Pandolfi. 2017. “MTORC1 and Muscle Regeneration Are Regulated by the LINC00961-Encoded SPAR Polypeptide.”. Nature 541 (7636): 228-32.

In Vivo Protocol Design and Implementation

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Agents alone or in combination will be evaluated in vivo in human tumor xenografts in mice, as well as in GEMs obtained by outsourcing or in-house acquisition when requested. We will evaluate each drug or combination of drugs by different routes or different schedules of administration following...

Of model pets and cancer models: an introduction to mouse models of cancer.

Publication: Journal Article

Lunardi, Andrea, Caterina Nardella, John G Clohessy, and Pier Paolo Pandolfi. 2014. “Of Model Pets and Cancer Models: An Introduction to Mouse Models of Cancer.”. Cold Spring Harbor Protocols 2014 (1): 17-31.

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.

Publication: Journal Article

Nardella, Caterina, Andrea Lunardi, Giuseppe Fedele, John G Clohessy, Andrea Alimonti, Sara C Kozma, George Thomas, Massimo Loda, and Pier Paolo Pandolfi. 2011. “Differential Expression of S6K2 Dictates Tissue-Specific Requirement for S6K1 in Mediating Aberrant MTORC1 Signaling and Tumorigenesis.”. Cancer Research 71 (10): 3669-75.

beta-tting on p63 as a metastatic suppressor.

Publication: Journal Article

Clohessy, John G, and Pier Paolo Pandolfi. 2009. “Beta-Tting on P63 As a Metastatic Suppressor.”. Cell 137 (1): 28-30.