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Of model pets and cancer models: an introduction to mouse models of cancer.

Publication: Journal Article

Lunardi, Andrea, Caterina Nardella, John G Clohessy, and Pier Paolo Pandolfi. 2014. “Of Model Pets and Cancer Models: An Introduction to Mouse Models of Cancer.”. Cold Spring Harbor Protocols 2014 (1): 17-31.

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.

Publication: Journal Article

Nardella, Caterina, Andrea Lunardi, Giuseppe Fedele, John G Clohessy, Andrea Alimonti, Sara C Kozma, George Thomas, Massimo Loda, and Pier Paolo Pandolfi. 2011. “Differential Expression of S6K2 Dictates Tissue-Specific Requirement for S6K1 in Mediating Aberrant MTORC1 Signaling and Tumorigenesis.”. Cancer Research 71 (10): 3669-75.

beta-tting on p63 as a metastatic suppressor.

Publication: Journal Article

Clohessy, John G, and Pier Paolo Pandolfi. 2009. “Beta-Tting on P63 As a Metastatic Suppressor.”. Cell 137 (1): 28-30.

Differential requirement of mTOR in postmitotic tissues and tumorigenesis.

Publication: Journal Article

Nardella, Caterina, Arkaitz Carracedo, Andrea Alimonti, Robin M Hobbs, John G Clohessy, Zhenbang Chen, Ainara Egia, et al. 2009. “Differential Requirement of MTOR in Postmitotic Tissues and Tumorigenesis.”. Science Signaling 2 (55): ra2.

In Vivo Protocol Design and Implementation

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Agents alone or in combination will be evaluated in vivo in human tumor xenografts in mice, as well as in GEMs obtained by outsourcing or in-house acquisition when requested. We will evaluate each drug or combination of drugs by different routes or different schedules of administration following...

PI3K drives the de novo synthesis of coenzyme A from vitamin B5.

Publication: Journal Article

Dibble, Christian C, Samuel A Barritt, Grace E Perry, Evan C Lien, Renee C Geck, Sarah E DuBois-Coyne, David Bartee, et al. 2022. “PI3K Drives the de Novo Synthesis of Coenzyme A from Vitamin B5.”. Nature 608 (7921): 192-98.

WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models.

Publication: Journal Article

Kishikawa, Takahiro, Hiroshi Higuchi, Limei Wang, Nivedita Panch, Valerie Maymi, Sachem Best, Samuel Lee, et al. 2021. “WWP1 Inactivation Enhances Efficacy of PI3K Inhibitors While Suppressing Their Toxicities in Breast Cancer Models.”. The Journal of Clinical Investigation 131 (24).

NF-κB Blockade with Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants.

Publication: Journal Article

Morel, Katherine L, Anis A Hamid, John G Clohessy, Nicole Pandell, Leigh Ellis, and Christopher J Sweeney. 2021. “NF-κB Blockade With Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants.”. Molecular Cancer Research : MCR 19 (7): 1137-45.

Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors.

Publication: Journal Article

Chin, Tan-Min, Gandhi T K Boopathy, Ellen P S Man, John G Clohessy, Eva Csizmadia, Margaret P Quinlan, Thomas Putti, et al. 2020. “Targeting Microtubules Sensitizes Drug Resistant Lung Cancer Cells to Lysosomal Pathway Inhibitors.”. Theranostics 10 (6): 2727-43.

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.

Publication: Journal Article

Lee, Yu-Ru, Ming Chen, Jonathan D Lee, Jinfang Zhang, Shu-Yu Lin, Tian-Min Fu, Hao Chen, et al. 2019. “Reactivation of PTEN Tumor Suppressor for Cancer Treatment through Inhibition of a MYC-WWP1 Inhibitory Pathway.”. Science (New York, N.Y.) 364 (6441).