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59 results found

Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation.

Publication: Journal Article

van de Ven, Anne L, Shifalika Tangutoori, Paige Baldwin, Ju Qiao, Codi Gharagouzloo, Nina Seitzer, John G Clohessy, et al. 2017. “Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation.”. Molecular Cancer Therapeutics 16 (7): 1279-89.

SPAR, a lncRNA encoded mTORC1 inhibitor.

Publication: Journal Article

Matsumoto, Akinobu, John G Clohessy, and Pier Paolo Pandolfi. 2017. “SPAR, a LncRNA Encoded MTORC1 Inhibitor.”. Cell Cycle (Georgetown, Tex.) 16 (9): 815-16.

The pleiotropic role of non-coding genes in development and cancer.

Publication: Journal Article

Pasut, Alessandra, Akinobu Matsumoto, John G Clohessy, and Pier Paolo Pandolfi. 2016. “The Pleiotropic Role of Non-Coding Genes in Development and Cancer.”. Current Opinion in Cell Biology 43: 104-13.

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.

Publication: Journal Article

Rau, Rachel, Daniel Magoon, Sarah Greenblatt, Li Li, Colleen Annesley, Amy S Duffield, David Huso, et al. 2014. “NPMc+ Cooperates With Flt3/ITD Mutations to Cause Acute Leukemia Recapitulating Human Disease.”. Experimental Hematology 42 (2): 101-13.e5.

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells.

Publication: Journal Article

Fagoonee, Sharmila, Claudia Bearzi, Ferdinando Di Cunto, John G Clohessy, Roberto Rizzi, Markus Reschke, Emanuela Tolosano, et al. 2013. “The RNA Binding Protein ESRP1 Fine-Tunes the Expression of Pluripotency-Related Factors in Mouse Embryonic Stem Cells.”. PloS One 8 (8): e72300.

Subtle variations in Pten dose determine cancer susceptibility.

Publication: Journal Article

Alimonti, Andrea, Arkaitz Carracedo, John G Clohessy, Lloyd C Trotman, Caterina Nardella, Ainara Egia, Leonardo Salmena, et al. 2010. “Subtle Variations in Pten Dose Determine Cancer Susceptibility.”. Nature Genetics 42 (5): 454-8.

Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer.

Publication: Journal Article

Montanaro, L, M Brigotti, J Clohessy, S Barbieri, C Ceccarelli, D Santini, M Taffurelli, et al. 2006. “Dyskerin Expression Influences the Level of Ribosomal RNA Pseudo-Uridylation and Telomerase RNA Component in Human Breast Cancer.”. The Journal of Pathology 210 (1): 10-8.

From Mouse to Human: History

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APL as a Novel Paradigm for Experimental Therapeutics Acute promyelocytic leukemia (APL) is associated with the accumulation in the bone marrow of tumor cells with promyelocytic features and the invariable association with specific reciprocal chromosomal translocations involving the retinoic acid...

Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs.

Publication: Journal Article

Zhang, Yang, Tuan M Nguyen, Xiao-Ou Zhang, Limei Wang, Tin Phan, John G Clohessy, and Pier Paolo Pandolfi. 2021. “Optimized RNA-Targeting CRISPR/Cas13d Technology Outperforms ShRNA in Identifying Functional CircRNAs.”. Genome Biology 22 (1): 41.

Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy.

Publication: Journal Article

Mugoni, Vera, Riccardo Panella, Giulia Cheloni, Ming Chen, Olga Pozdnyakova, Dina Stroopinsky, Jlenia Guarnerio, et al. 2019. “Vulnerabilities in MIDH2 AML Confer Sensitivity to APL-Like Targeted Combination Therapy.”. Cell Research 29 (6): 446-59.