Search

Search results

59 results found

Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue

Okada, Kosuke, Katherine B. LeClair, Yongzhao Zhang, Yingxia Li, Cafer Ozdemir, Tibor I. Krisko, Susan J. Hagen, Rebecca A. Betensky, Alexander S. Banks, and David E. Cohen. 2016. “Thioesterase Superfamily Member 1 Suppresses Cold Thermogenesis by Limiting the Oxidation of Lipid Droplet-Derived Fatty Acids in Brown Adipose Tissue”. Molecular Metabolism.

Welcome Prasad!

Welcome Prasad! He joined the lab as a postdoctoral fellow this March.

Body Composition Systems

EchoMRI 3-in-1 body composition analyzer Measures live mice up to 100g, tissue samples of 10g, and biopsy samples up to 0.1g Measurements include lean mass, fat mass, and water mass 3-5 minutes per mouse No anesthesia required

Research Area 2: Methods to Study Energy Balance in Mice

We use indirect calorimetry systems to measure metabolic rates, physical activity, and food intake in laboratory animals. These components impact energy balance and body weight. These indirect calorimetry systems generate a flood of raw data that requires time-consuming manual manipulation for...

Thermogenesis: Cold Temperature Challenge

Male C57Bl/6J mice (10–14 weeks, JAX) were monitored in the Promethion indirect calorimeter at 30°C, 23°C, and 4°C, tracking body weight and energy expenditure, with data analyzed in CalR. ​

Continuous glucose monitoring (CGM) : Telemetry

Indirect calorimetry data for one mouse implanted with a glucose and body temperature telemetry probe in the Promethion indirect calorimeter. Food was removed 1 h before start of the dark photoperiod (grey) and mice enter bouts of torpor (Rubio et al Mol Metabolism 2023)​

Germ-free mice

Germ-free mice can be examined using isolator cages (bottom). With this approach, we canexamine the metabolic profile of germ-free mice or mice colonized with specific microbes. ​

Infrared thermal imaging (FLIR)

Thermal imaging was performed using FLIR on juvenile mice placed in a sterile 6-well culture dish to visualize body temperature distribution.