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Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines.

Publication: Journal Article

James, David A, Keizo Koya, Hao Li, Guiqing Liang, Zhiqiang Xia, Weiwen Ying, Yaming Wu, and Lijun Sun. 2008. “Indole- and Indolizine-Glyoxylamides Displaying Cytotoxicity Against Multidrug Resistant Cancer Cell Lines.”. Bioorganic & Medicinal Chemistry Letters 18 (6): 1784-7.

2024 BIDMC Annual Research Retreat

News: September 05, 2024

Simon Lab members attended the research retreat. Alejandra and Emily presented "Pharmacological stabilization of the retromer complex results in the reduction of α-synuclein accumulation and in the control of α-synuclein clearance pathways" and joined in conversations about the latest research at...

Extracellular vesicles show promise for cancer theranostics.

Publication: Journal Article

Segal, Meirav, and Frank J Slack. 2019. “Extracellular Vesicles Show Promise for Cancer Theranostics.”. Annals of Translational Medicine 7 (7): 158.

Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.

Publication: Journal Article

Jiao, Alan L, Roberto Perales, Neil T Umbreit, Jeffrey R Haswell, Mary E Piper, Brian D Adams, David Pellman, Scott Kennedy, and Frank J Slack. 2019. “Human Nuclear RNAi-Defective 2 (NRDE2) Is an Essential RNA Splicing Factor.”. RNA (New York, N.Y.) 25 (3): 352-63.

A microRNA feedback loop regulates global microRNA abundance during aging.

Publication: Journal Article

Inukai, Sachi, Zachary Pincus, Alexandre de Lencastre, and Frank J Slack. 2018. “A MicroRNA Feedback Loop Regulates Global MicroRNA Abundance During Aging.”. RNA (New York, N.Y.) 24 (2): 159-72.

acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes.

Publication: Journal Article

Metheetrairut, Chanatip, Yuri Ahuja, and Frank J Slack. 2017. “Acn-1, a C. Elegans Homologue of ACE, Genetically Interacts With the Let-7 MicroRNA and Other Heterochronic Genes.”. Cell Cycle (Georgetown, Tex.) 16 (19): 1800-1809.

OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer.

Publication: Journal Article

Svoronos, Alexander A, Donald M Engelman, and Frank J Slack. 2016. “OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer.”. Cancer Research 76 (13): 3666-70.

miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage.

Publication: Journal Article

Salzman, David W, Kotoka Nakamura, Sunitha Nallur, Michelle T Dookwah, Chanatip Metheetrairut, Frank J Slack, and Joanne B Weidhaas. 2016. “MiR-34 Activity Is Modulated through 5’-End Phosphorylation in Response to DNA Damage.”. Nature Communications 7: 10954.

Cancer. Malicious exosomes.

Publication: Journal Article

Anastasiadou, Eleni, and Frank J Slack. 2014. “Cancer. Malicious Exosomes.”. Science (New York, N.Y.) 346 (6216): 1459-60.

Aberrant regulation and function of microRNAs in cancer.

Publication: Journal Article

Adams, Brian D, Andrea L Kasinski, and Frank J Slack. 2014. “Aberrant Regulation and Function of MicroRNAs in Cancer.”. Current Biology : CB 24 (16): R762-76.